General Information

    • DRAMP ID

    • DRAMP29959

    • Peptide Name

    • C6a

    • Source

    • Synthetic construct(derived from gp36 membrane proximal external region of FIV)

    • Family

    • Retroviridae

    • Gene

    • Not found

    • Sequence

    • DWVRWI

    • Sequence Length

    • 6

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • [Ref.30240422]Feline immunodeficiency virus (FIV): inhibition of virus replication in lymphoid cells(IC50=0.06-0.15 μg/ml).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • No cytotoxicity information or data found in the reference(s) presented in this entry

    • Binding Target

    • membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP29959 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29959.

Physicochemical Information

    • Formula

    • C43H59N11O9

    • Absent Amino Acids

    • ACEFGHKLMNPQSTY

    • Common Amino Acids

    • W

    • Mass

    • 874.01

    • PI

    • 5.84

    • Basic Residues

    • 1

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 4

    • Net Charge

    • 0

    • Boman Index

    • -1002

    • Hydrophobicity

    • -0.183

    • Aliphatic Index

    • 113.33

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 11000

    • Absorbance 280nm

    • 2200

    • Polar Residues

    • 0

DRAMP29959

Comments Information

    • Mechanism

    • Elicit antiviral activity by inhibiting the fusion of the FIV and host cell membrane.

Literature Information

  • ·Literature 1

    • Title

    • Structural basis of antiviral activity of peptides from MPER of FIV gp36

    • Reference

    • PLoS One. 2018 Sep 21;13(9):e0204042

    • Author

    • Grimaldi M, Stillitano I, Amodio G, Santoro A, Buonocore M, Moltedo O, Remondelli P, D'Ursi AM.