General Information
-
DRAMP ID
- DRAMP29960
-
Peptide Name
- C8
-
Source
- Synthetic construct(derived from gp36 membrane proximal external region of FIV)
-
Family
- Retroviridae
-
Gene
- Not found
-
Sequence
- WEDWVRWI
-
Sequence Length
- 8
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
-
Target Organism
-
- [Ref.30240422]Feline immunodeficiency virus (FIV): inhibition of virus replication in lymphoid cells(IC50=0.05-0.06 μg/ml).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- No cytotoxicity information or data found in the reference(s) presented in this entry
-
Binding Target
- membrane
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP29960.
Physicochemical Information
-
Formula
- C59H76N14O13
Absent Amino Acids
- ACFGHKLMNPQSTY
Common Amino Acids
- W
Mass
- 1189.34
PI
- 4.37
Basic Residues
- 1
Acidic Residues
- 2
Hydrophobic Residues
- 5
Net Charge
- -1
-
Boman Index
- -1450
Hydrophobicity
- -0.688
Aliphatic Index
- 85
Half Life
-
- Mammalian:2.8 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 16500
Absorbance 280nm
- 2357.14
Polar Residues
- 0
DRAMP29960
Comments Information
Mechanism
- Elicit antiviral activity by inhibiting the fusion of the FIV and host cell membrane.
Literature Information
- ·Literature 1
-
Title
- Structural basis of antiviral activity of peptides from MPER of FIV gp36
-
Pubmed ID
- 30240422
-
Reference
- PLoS One. 2018 Sep 21;13(9):e0204042
-
Author
- Grimaldi M, Stillitano I, Amodio G, Santoro A, Buonocore M, Moltedo O, Remondelli P, D'Ursi AM.