General Information

    • DRAMP ID

    • DRAMP29961

    • Peptide Name

    • Chol-PEG4-VG

    • Source

    • Synthetic construct

    • Family

    • Paramyxoviridae

    • Gene

    • Not found

    • Sequence

    • XGSGSGVALDPIDIAnti-SIVLNKAKSDLEESKEWIRRSNGKLDSI

    • Sequence Length

    • 42

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • [Ref.28344321]Human parainfluenza viruse 3(HPIV 3): inhibition of virus infection in Vero cells(IC90=0.1 ± 0.0001 nM,IC50<0.0007 nM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • [Ref.28344321]Vero cells: CC50>10000 nM.

    • Binding Target

    • membrane

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Acetylation

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • The 'X' at position 1 indicates cholesterol-PEG4 conjugated cysteine.

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP29961 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29961.

Physicochemical Information

    • Formula

    • C190H316N54O64

    • Absent Amino Acids

    • CFHMQTY

    • Common Amino Acids

    • S

    • Mass

    • 4510.27

    • PI

    • 5.05

    • Basic Residues

    • 6

    • Acidic Residues

    • 7

    • Hydrophobic Residues

    • 14

    • Net Charge

    • -1

    • Boman Index

    • -8236

    • Hydrophobicity

    • -0.383

    • Aliphatic Index

    • 102.14

    • Half Life

      • Mammalian:
      • Yeast:
      • E.coli:

    • Extinction Coefficient Cystines

    • 5500

    • Absorbance 280nm

    • 134.15

    • Polar Residues

    • 13

DRAMP29961

DRAMP29961 chydropathy plot

Comments Information

    • Mechanism

    • Peptides derived from the HRC of paramyxovirus F proteins interfere with formation of the six-helix bundle in a dominant-negative manner by binding to the transiently exposed HRN coiled coil in the transient fusion intermediate, thereby inhibiting membrane fusion.

Literature Information

  • ·Literature 1

    • Title

    • Broad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides

    • Reference

    • Sci Rep. 2017 Mar 8;7:43610.

    • Author

    • Mathieu C, Augusto MT, Niewiesk S, Horvat B, Palermo LM, Sanna G, Madeddu S, Huey D, Castanho MA, Porotto M, Santos NC, Moscona A