General Information
-
DRAMP ID
- DRAMP29962
-
Peptide Name
- Chol-VG
-
Source
- Synthetic construct
-
Family
- Paramyxoviridae
-
Gene
- Not found
-
Sequence
- XGSGSGVALDPIDIAnti-SIVLNKAKSDLEESKEWIRRSNGKLDSI
-
Sequence Length
- 42
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
-
Target Organism
-
- [Ref.28344321]Human parainfluenza viruse 3(HPIV 3): inhibition of virus infection in Vero cells(IC90=1.7 ± 0.42 nM,IC50=0.06 ± 0.035 nM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- [Ref.28344321]Vero cells: CC50=9000 nM.
-
Binding Target
- membrane
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Acetylation
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- The 'X' at position 1 indicates cholesterol-conjugated cysteine.
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP29962.
Physicochemical Information
-
Formula
- C190H316N54O64
Absent Amino Acids
- CFHMQTY
Common Amino Acids
- S
Mass
- 4510.27
PI
- 5.05
Basic Residues
- 6
Acidic Residues
- 7
Hydrophobic Residues
- 14
Net Charge
- -1
-
Boman Index
- -8236
Hydrophobicity
- -0.383
Aliphatic Index
- 102.14
Half Life
-
- Mammalian:
- Yeast:
- E.coli:
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 134.15
Polar Residues
- 13
DRAMP29962
![DRAMP29962 chydropathy plot](http://dramp.cpu-bioinfor.org/tmp/all_info_png/pepwindow_DRAMP29962.1.png)
Comments Information
Mechanism
- Peptides derived from the HRC of paramyxovirus F proteins interfere with formation of the six-helix bundle in a dominant-negative manner by binding to the transiently exposed HRN coiled coil in the transient fusion intermediate, thereby inhibiting membrane fusion.
Literature Information
- ·Literature 1
-
Title
- Broad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides
-
Pubmed ID
- 28344321
-
Reference
- Sci Rep. 2017 Mar 8;7:43610.
-
Author
- Mathieu C, Augusto MT, Niewiesk S, Horvat B, Palermo LM, Sanna G, Madeddu S, Huey D, Castanho MA, Porotto M, Santos NC, Moscona A