General Information

    • DRAMP ID

    • DRAMP30295

    • Peptide Name

    • Clavanin-B (His-rich; chordates, animals)

    • Source

    • Styela clava (Sea squirt)

    • Family

    • Retroviridae

    • Gene

    • Not found

    • Sequence

    • VFQFLGRIIAnti-HHVGNFVHGFSHVF

    • Sequence Length

    • 23

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • [Ref.20086159]HIV-1 IIIB:inhibition the cytopathic effects of HIV-1 infection in CEM-SS cells(EC50=7.1 μM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • [Ref.20086159]CEM-SS cells:50% Cell death at 37.1 µM.

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP30295 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP30295.

Physicochemical Information

    • Formula

    • C131H184N36O27

    • Absent Amino Acids

    • ACDEKMPTWY

    • Common Amino Acids

    • F

    • Mass

    • 2695.13

    • PI

    • 9.75

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 12

    • Net Charge

    • +5

    • Boman Index

    • -50

    • Hydrophobicity

    • 0.752

    • Aliphatic Index

    • 101.3

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 5

DRAMP30295

DRAMP30295 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database.

    • Reference

    • Antimicrob Agents Chemother. 2010 Mar;54(3):1343-6.

    • Author

    • Wang G, Watson KM, Peterkofsky A, Buckheit RW Jr.