General Information
-
DRAMP ID
- DRAMP30310
-
Peptide Name
- Caerin 1.9 sm(Caerin 1.9 [V13L])
-
Source
- Sythetic construct(derived from Caerin 1.9)
-
Family
- Retroviridae
-
Gene
- Not found
-
Sequence
- GLFGVLGSIAKHLLPHVVPVIAEKL
-
Sequence Length
- 25
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
-
Target Organism
-
- [Ref.26026377]Human immunodeficiency virus (HIV): inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=3 µM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- [Ref.26026377]CD4+ T Lymphocytes:50% cell death at 17.5 µM.
-
Binding Target
- virion envelope
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP30310.
Physicochemical Information
-
Formula
- C125H207N31O29
Absent Amino Acids
- CDMNQRTWY
Common Amino Acids
- L
Mass
- 2608.21
PI
- 8.61
Basic Residues
- 4
Acidic Residues
- 1
Hydrophobic Residues
- 14
Net Charge
- +3
-
Boman Index
- 2939
Hydrophobicity
- 1.132
Aliphatic Index
- 163.6
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 4
DRAMP30310
Comments Information
Mechanism
- [Ref.26026377]Inhibit the infection of HIV by disrupting the HIV envelope and release viral core protein (p24).
Literature Information
- ·Literature 1
-
Title
- VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.
-
Pubmed ID
- 26026377
-
Reference
- Peptides. 2015 Sep;71:296-303.
-
Author
- Inhibition of HIV infection by caerin 1 antimicrobial peptides.
- ·Literature 2
-
Title
- Rollins-Smith LA, Smith PB, Ledeczi AM, Rowe JM, Reinert LK.
-
Pubmed ID
- 33008028
-
Reference
- Antibiotics (Basel). 2020 Sep 30;9(10):661.
-
Author
- Caerin 1 Antimicrobial Peptides That Inhibit HIV and Neisseria May Spare Protective Lactobacilli.