General Information

    • DRAMP ID

    • DRAMP30311

    • Peptide Name

    • Caerin 1.20

    • Source

    • Litoria caerulea/Litoria splendida

    • Family

    • Retroviridae

    • Gene

    • Not found

    • Sequence

    • GLFGILGSVAKHVLPHVIPVVAEHL

    • Sequence Length

    • 25

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • [Ref.26026377]Human immunodeficiency virus (HIV): inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells(IC50=7 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • [Ref.26026377]CD4+ T Lymphocytes:50% cell death at 25 µM;Human endocervical cells End1/E6E7:50% cell death at 22 µM.

    • Binding Target

    • virion envelope

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP30311 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP30311.

Physicochemical Information

    • Formula

    • C124H200N32O29

    • Absent Amino Acids

    • CDMNQRTWY

    • Common Amino Acids

    • V

    • Mass

    • 2603.15

    • PI

    • 7.02

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +3

    • Boman Index

    • 2940

    • Hydrophobicity

    • 1.176

    • Aliphatic Index

    • 159.6

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP30311

DRAMP30311 chydropathy plot

Comments Information

    • Mechanism

    • [Ref.26026377]Inhibit the infection of HIV by disrupting the HIV envelope and release viral core protein (p24).

Literature Information

  • ·Literature 1

    • Title

    • VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA.

    • Reference

    • Peptides. 2015 Sep;71:296-303.

    • Author

    • Inhibition of HIV infection by caerin 1 antimicrobial peptides.
  • ·Literature 2

    • Title

    • Rollins-Smith LA, Smith PB, Ledeczi AM, Rowe JM, Reinert LK.

    • Reference

    • Antibiotics (Basel). 2020 Sep 30;9(10):661.

    • Author

    • Caerin 1 Antimicrobial Peptides That Inhibit HIV and Neisseria May Spare Protective Lactobacilli.