• • DRAMP ID

  • DRAMP30385

• • Peptide Name

  • MT-WQ-IDL(626-656)

• • Source

  • Synthetic construct

• • Family

  • Retroviridae

• • Gene

  • Not found

• • Sequence

  • MTWEEWDKKIEEYTKKIEELIKKSQNQQIDL

• • Sequence Length

  • 31

• • UniProt Entry

  • P04578

• • Protein Existence

  • Not found

• • SMILES

  • CC[C@@H](C)[C@H](NC(=O)C[C@H](NC(=O)[C@H](CCC(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](N)CCSC)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@H](C)CC)[C@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)O)[C@@H](C)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)O)[C@H](C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)O

• • Biological Activity

  • Antimicrobial, Antiviral

• • Target Organism

  • • [Ref.27795416]HIV-1 IIIB:

      Target Organism	Activity
      inhibition of virus infection in MT-2 cells(IC50=0.6±0.1 nM); inhibition of peptide against cell-cell fusion between H9/HIV-1 IIIB cells and MT-2 cells	IC50=1.2± 0.2 nM

    • HIV-1 Bal:

      Target Organism	Activity
      inhibition of virus infection in MT-2 cells	IC50=0.6 ±0.1 nM

    • HIV-1 clinical isolates(8 clinical isolates):

      Target Organism	Activity
      inhibition of virus infection in MT-2 cells	IC50=0.5-15.1 nM

    • HIV-1 pseudoviruses(7 pseudoviruses):

      Target Organism	Activity
      inhibition of pseudoviruses infection in MT-2 cells	IC50=0.1-9.0 nM

    • HIV-1 T20-resistant strains(5 strains):

      Target Organism	Activity
      inhibition of virus infection in MT-2 cells	IC50=0.1-4.4 nM

    • HIV-1 T2635-resistant strain(6 strains):

      Target Organism	Activity
      inhibition of virus infection in MT-2 cells	IC50=1.1-11.3 nM

• • Hemolytic Activity

  • • No hemolysis information or data found in the reference(s) presented in this entry

• • Cytotoxicity

  • No cytotoxicity information found in the reference(s) presented

• • Binding Target

  • membrane

• • Linear/Cyclic

  • Linear

• • N-terminal Modification

  • Free

• • C-terminal Modification

  • Free

• • Nonterminal Modifications and Unusual Amino Acids

  • None

• • Stereochemistry

  • L

• • Structure

  • Not found

• • Structure Description

  • Not found

• • PDB ID

  • None

• Predicted Structure

• Please click DRAMP30385_predicted_structure.pdb to download.

DRAMP30385

• • Mechanism

  • The peptide inhibits HIV fusion by binding to the hydrophobic grooves on the N-terminal heptad repeat (NHR) trimer and blocking six-helix-bundle (6-HB) formation.

• ·Literature 1

• • Title

  • Creating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors.

• • Pubmed ID

  • 27795416

• • Reference

  • J Virol. 2016 Dec 16;91(1):e01445-16.

• • Author

  • Su S, Zhu Y, Ye S, Qi Q, Xia S, Ma Z, Yu F, Wang Q, Zhang R, Jiang S, Lu L.