General Information
-
DRAMP ID
- DRAMP30387
-
Peptide Name
- M0
-
Source
- Synthetic construct
-
Family
- Coronaviridae
-
Gene
- Not found
-
Sequence
- TTLLDLTYEMLSLQQVVKALNESYIDLKEL
-
Sequence Length
- 30
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
-
Target Organism
-
- [Ref.27795416]MERS-CoV:inhibition of MERS-CoV S-medicated cell-cell fusion in MT-2 cells(IC50=4.5 μM);inhibition of pseudovirus infection in MT-2 cells(IC50=17.8 μM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- membrane
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP30387.
Physicochemical Information
-
Formula
- C157H259N35O51S
Absent Amino Acids
- CFGHPRW
Common Amino Acids
- L
Mass
- 3485.05
PI
- 4.18
Basic Residues
- 2
Acidic Residues
- 5
Hydrophobic Residues
- 12
Net Charge
- -3
-
Boman Index
- -2496
Hydrophobicity
- 0.163
Aliphatic Index
- 139.67
Half Life
-
- Mammalian:7.2 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 2980
Absorbance 280nm
- 102.76
Polar Residues
- 8
DRAMP30387
Comments Information
Mechanism
- The peptide inhibits HIV fusion by binding to the hydrophobic grooves on the N-terminal heptad repeat (NHR) trimer and blocking six-helix-bundle (6-HB) formation.
Literature Information
- ·Literature 1
-
Title
- Creating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors.
-
Pubmed ID
- 27795416
-
Reference
- J Virol. 2016 Dec 16;91(1):e01445-16.
-
Author
- Su S, Zhu Y, Ye S, Qi Q, Xia S, Ma Z, Yu F, Wang Q, Zhang R, Jiang S, Lu L.