General Information

    • DRAMP ID

    • DRAMP30394

    • Peptide Name

    • peptide 9

    • Source

    • Synthetic construct

    • Family

    • Retroviridae

    • Gene

    • Not found

    • Sequence

    • IIRILQQLLFIHFRIGRRRRRRRR

    • Sequence Length

    • 24

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • [Ref.20708407]HIV-1:Inhibition of 3′-processing catalyzed by integrase(IC50=0.11 ± 0.01 µM);inhibition of strand transfer catalyzed by integrase(IC50=0.07 ± 0.01 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • No cytotoxicity information or data found in the reference(s) presented in this entry

    • Binding Target

    • Integrase

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Acetylation

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP30394 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP30394.

Physicochemical Information

    • Formula

    • C144H254N58O27

    • Absent Amino Acids

    • ACDEKMNPSTVWY

    • Common Amino Acids

    • R

    • Mass

    • 3229.97

    • PI

    • 12.95

    • Basic Residues

    • 11

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +11

    • Boman Index

    • -11868

    • Hydrophobicity

    • -0.671

    • Aliphatic Index

    • 130

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP30394

DRAMP30394 chydropathy plot

Comments Information

    • Mechanism

    • The peptide acts antiviral activity by inhibiting the activity of integrase.

Literature Information

  • ·Literature 1

    • Title

    • Peptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies.

    • Reference

    • Bioorg Med Chem. 2010 Sep 15;18(18):6771-5.

    • Author

    • Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H.