General Information

    • DRAMP ID

    • DRAMP30398

    • Peptide Name

    • peptide 13

    • Source

    • Synthetic construct

    • Family

    • Retroviridae

    • Gene

    • Not found

    • Sequence

    • EAIIRILQELLFKHFRIGRRRRRRRR

    • Sequence Length

    • 26

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • [Ref.20708407]HIV-1:Inhibition of 3′-processing catalyzed by integrase(IC50=0.14 ± 0.02 µM);inhibition of strand transfer catalyzed by integrase(IC50=0.065 ± 0.01 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • No cytotoxicity information or data found in the reference(s) presented in this entry

    • Binding Target

    • Integrase

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Acetylation

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP30398 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP30398.

Physicochemical Information

    • Formula

    • C152H266N60O32

    • Absent Amino Acids

    • CDMNPSTVWY

    • Common Amino Acids

    • R

    • Mass

    • 3446.17

    • PI

    • 12.37

    • Basic Residues

    • 12

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 10

    • Net Charge

    • +10

    • Boman Index

    • -13542

    • Hydrophobicity

    • -1.008

    • Aliphatic Index

    • 108.85

    • Half Life

      • Mammalian:1 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 1

DRAMP30398

DRAMP30398 chydropathy plot

Comments Information

    • Mechanism

    • The peptide acts antiviral activity by inhibiting the activity of integrase.

Literature Information

  • ·Literature 1

    • Title

    • Peptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies.

    • Reference

    • Bioorg Med Chem. 2010 Sep 15;18(18):6771-5.

    • Author

    • Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H.