General Information
-
DRAMP ID
- DRAMP30402
-
Peptide Name
- peptide 17
-
Source
- Synthetic construct
-
Family
- Retroviridae
-
Gene
- Not found
-
Sequence
- EEIIRKLQQLLFIEFRIKRRRRRRRR
-
Sequence Length
- 26
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
-
Target Organism
-
- [Ref.20708407]HIV-1:Inhibition of 3′-processing catalyzed by integrase(IC50=0.18 ± 0.06 µM);inhibition of strand transfer catalyzed by integrase(IC50=0.08 ± 0.02 µM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- No cytotoxicity information or data found in the reference(s) presented in this entry
-
Binding Target
- Integrase
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Acetylation
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP30402.
Physicochemical Information
-
Formula
- C157H278N60O35
Absent Amino Acids
- ACDGHMNPSTVWY
Common Amino Acids
- R
Mass
- 3566.32
PI
- 12.18
Basic Residues
- 12
Acidic Residues
- 3
Hydrophobic Residues
- 9
Net Charge
- +9
-
Boman Index
- -15141
Hydrophobicity
- -1.358
Aliphatic Index
- 105
Half Life
-
- Mammalian:1 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 0
Absorbance 280nm
- 0
Polar Residues
- 0
DRAMP30402
Comments Information
Mechanism
- The peptide acts antiviral activity by inhibiting the activity of integrase.
Literature Information
- ·Literature 1
-
Title
- Peptidic HIV integrase inhibitors derived from HIV gene products: structure-activity relationship studies.
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Pubmed ID
- 20708407
-
Reference
- Bioorg Med Chem. 2010 Sep 15;18(18):6771-5.
-
Author
- Suzuki S, Maddali K, Hashimoto C, Urano E, Ohashi N, Tanaka T, Ozaki T, Arai H, Tsutsumi H, Narumi T, Nomura W, Yamamoto N, Pommier Y, Komano JA, Tamamura H.