General Information

    • DRAMP ID

    • DRAMP31562

    • Peptide Name

    • Peptide1(ACE2 (21-43)[N13Q,A16V,D18E,L19I,F20Y,Y21W])

    • Source

    • Synthetic construct

    • Family

    • Coronaviridae

    • Gene

    • Not found

    • Sequence

    • IEEQAKTFLDKFQAnti-HeVEEIYWQS

    • Sequence Length

    • 23

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antiviral

    • Target Organism

      • [Ref.34328726]SARS-CoV-2:Inhibition of virus entry in HEK293T/ACE2 cells (via inhibition of SRBD:ACE2 interaction)(IC50=11 ± 1 nM, 100% inhibition at 25 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • No cytotoxicity information or data found in the reference(s) presented in this entry

    • Binding Target

    • Spike protein

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Amidation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP31562 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP31562.

Physicochemical Information

    • Formula

    • C133H193N31O42

    • Absent Amino Acids

    • CGMNPR

    • Common Amino Acids

    • E

    • Mass

    • 2898.18

    • PI

    • 4.41

    • Basic Residues

    • 3

    • Acidic Residues

    • 6

    • Hydrophobic Residues

    • 8

    • Net Charge

    • -3

    • Boman Index

    • -5236

    • Hydrophobicity

    • -0.948

    • Aliphatic Index

    • 67.83

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 6990

    • Absorbance 280nm

    • 317.73

    • Polar Residues

    • 3

DRAMP31562

DRAMP31562 chydropathy plot

Comments Information

    • Mechanism

    • antagonizes the SARS-CoV-2 S-RBD

Literature Information

  • ·Literature 1

    • Title

    • Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein

    • Reference

    • J Med Chem. 2022 Feb 24;65(4):2836-2847. 

    • Author

    • Sadremomtaz A, Al-Dahmani ZM, Ruiz-Moreno AJ, Monti A, Wang C, Azad T, Bell JC, Doti N, Velasco-Velázquez MA, de Jong D, de Jonge J, Smit J, Dömling A, van Goor H, Groves MR.