General Information
-
DRAMP ID
- DRAMP31564
-
Peptide Name
- Peptide3
-
Source
- Synthetic construct
-
Family
- Coronaviridae
-
Gene
- Not found
-
Sequence
- DKFNHEAEDLFYQSSLASWNYNT
-
Sequence Length
- 23
-
UniProt Entry
- Q9BYF1
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antiviral
-
Target Organism
-
- [Ref.34328726]SARS-CoV-2:Inhibition of virus entry in HEK293T/ACE2 cells (via inhibition of SRBD:ACE2 interaction)(IC50=6 ± 4 nM, 100% inhibition at 25 µM).
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- No cytotoxicity information or data found in the reference(s) presented in this entry
-
Binding Target
- Spike protein
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Amidation
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP31564.
Physicochemical Information
-
Formula
- C125H171N31O42
Absent Amino Acids
- CGIMPRV
Common Amino Acids
- NS
Mass
- 2779.92
PI
- 4.31
Basic Residues
- 2
Acidic Residues
- 4
Hydrophobic Residues
- 7
Net Charge
- -2
-
Boman Index
- -5803
Hydrophobicity
- -1.083
Aliphatic Index
- 42.61
Half Life
-
- Mammalian:1.1 hour
- Yeast:3 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 8480
Absorbance 280nm
- 385.45
Polar Residues
- 9
DRAMP31564
Comments Information
Mechanism
- antagonizes the SARS-CoV-2 S-RBD
Literature Information
- ·Literature 1
-
Title
- Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein
-
Pubmed ID
- 34328726
-
Reference
- J Med Chem. 2022 Feb 24;65(4):2836-2847.
-
Author
- Sadremomtaz A, Al-Dahmani ZM, Ruiz-Moreno AJ, Monti A, Wang C, Azad T, Bell JC, Doti N, Velasco-Velázquez MA, de Jong D, de Jonge J, Smit J, Dömling A, van Goor H, Groves MR.