General Information

    • DRAMP ID

    • DRAMP31667

    • Peptide Name

    • Gramicidin S

    • Source

    • Bacillus brevis

    • Family

    • Gene

    • Not found

    • Sequence

    • VXLfPVXLfP

    • Sequence Length

    • 10

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

      • Tumor cells: HeLa (LC50=7.4 µM); A549 (LC50=7.5 µM)

    • Hemolytic Activity

      • Human erythrocytes: 100% Hemolysis=39 µg/ml; 50% Hemolysis=11 µM; Sheep erythrocytes: 50% Hemolysis=21.1±2.6 µM; 100% Hemolysis=100 µM

    • Cytotoxicity

      • Not available

    • Binding Target

    • Not available

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • X=Orn; f=D-Phe

    • Stereochemistry

    • Mix

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP31667 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP31667.

Physicochemical Information

    • Formula

    • C32H48N6O3

    • Absent Amino Acids

    • ACDEFGHIKMNQRSTWY

    • Common Amino Acids

    • LPVX

    • Mass

    • 94548

    • PI

    • 6.11

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 4

    • Net Charge

    • 0

    • Boman Index

    • 1792

    • Hydrophobicity

    • 1.28

    • Aliphatic Index

    • 136

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP31667

Comments Information

    • Not available

Literature Information

  • ·Literature 1

    • Title

    • Inhibition of malaria parasite blood stages by tyrocidines, membrane-active cyclic peptide antibiotics from Bacillus brevis

    • Reference

    • Biochim Biophys Acta. 2007 Jun;1768(6):1488-97.

    • Author

    • Rautenbach M, Vlok NM, Stander M, Hoppe HC.