General Information

    • DRAMP ID

    • DRAMP31984

    • Peptide Name

    • Cyclosporin A

    • Source

    • Tolypocladium inflatum

    • Family

    • Gene

    • Not found

    • Sequence

    • XXXVXAaXXXX

    • Sequence Length

    • 11

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

      • Tumor cells: CaCo-2 (0% Killing=12µM; 20% Killing=17µM); Huh-7 (0% Killing=8µM; 50% Killing=17µM)

    • Hemolytic Activity

      • Not available

    • Cytotoxicity

      • Vero E6: <10% Killing=5µM, 25% Killing=17µM; Fcwf-4: 0% Killing=4µM, 40% Killing=12µM

    • Binding Target

    • Not available

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • X(1)=alpha-Aminobutyrate; X(2)=Sarcosine; X(3)=METH-Leu; X(5)=METH-Leu; X(7)=D-Ala; X(8)=METH-Leu; X(9)=METH-Leu; X(10)=METH-Val; X(11)=N-methyl-(4R)-4-[(E)-but-2-enyl]-4-methyl-L-threonyl

    • Stereochemistry

    • Mix

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP31984 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP31984.

Physicochemical Information

    • Formula

    • C8H-2N2O-6

    • Absent Amino Acids

    • CDEFGHIKLMNPQRSTW

    • Common Amino Acids

    • X

    • Mass

    • 108463

    • PI

    • 6.11

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 2

    • Net Charge

    • 0

    • Boman Index

    • 585

    • Hydrophobicity

    • 0.546

    • Aliphatic Index

    • 35.45

    • Half Life

      • Mammalian:/
      • Yeast:/
      • E.coli:/

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP31984

Comments Information

    • Not available

Literature Information

  • ·Literature 1

    • Title

    • A Short Double-Stapled Peptide Inhibits Respiratory Syncytial Virus Entry and Spreading

    • Reference

    • Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02241-16.

    • Author

    • Gaillard V, Galloux M, Garcin D, Eléouët JF, Le Goffic R, Larcher T, Rameix-Welti MA, Boukadiri A, Héritier J, Segura JM, Baechler E, Arrell M, Mottet-Osman G, Nyanguile O.