General Information

    • DRAMP ID

    • DRAMP34352

    • Peptide Name

    • Phomafungin

    • Source

    • Fungi

    • Family

    • Gene

    • Not found

    • Sequence

    • AXEGSnXX

    • Sequence Length

    • 8

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

    • Not available

    • Hemolytic Activity

      • Not available

    • Cytotoxicity

      • Not available

    • Binding Target

    • Not available

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • 3-OH-Me-C16

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • Mix

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP34352 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP34352.

Physicochemical Information

    • Formula

    • C13H14N4O4

    • Absent Amino Acids

    • CDFHIKLMNPQRTVWY

    • Common Amino Acids

    • X

    • Mass

    • 74531

    • PI

    • 3.85

    • Basic Residues

    • 0

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 1

    • Net Charge

    • -1

    • Boman Index

    • -746

    • Hydrophobicity

    • -0.363

    • Aliphatic Index

    • 12.5

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 2

DRAMP34352

Comments Information

    • Not available

Literature Information

  • ·Literature 1

    • Title

    • Isolation, structure and biological activity of phomafungin, a cyclic lipodepsipeptide from a widespread tropical Phoma sp

    • Reference

    • Bioorg Med Chem. 2009 Feb 1;17(3):1361-9.

    • Author

    • Herath K, Harris G, Jayasuriya H, Zink D, Smith S, Vicente F, Bills G, Collado J, González A, Jiang B, Kahn JN, Galuska S, Giacobbe R, Abruzzo G, Hickey E, Liberator P, Xu D, Roemer T, Singh SB.