General Information

    • DRAMP ID

    • DRAMP35979

    • Peptide Name

    • C12-PLL26

    • Source

    • Synthetic

    • Family

    • Gene

    • Not found

    • Sequence

    • LLLLLLLLLLLLLLLLLLLLLLLLLL

    • Sequence Length

    • 26

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

      • Tumor cells: C26 (IC50=15µg/mL)

    • Hemolytic Activity

      • Not available

    • Cytotoxicity

      • HUVEC: IC50=44µg/mL

    • Binding Target

    • Not available

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • C12

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP35979 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP35979.

Physicochemical Information

    • Formula

    • C156H288N26O27

    • Absent Amino Acids

    • ACDEFGHIKMNPQRSTV

    • Common Amino Acids

    • L

    • Mass

    • 340636

    • PI

    • 6.11

    • Basic Residues

    • 0

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 26

    • Net Charge

    • 0

    • Boman Index

    • 12792

    • Hydrophobicity

    • 3.8

    • Aliphatic Index

    • 390

    • Half Life

      • Mammalian:5.5 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 0

DRAMP35979

DRAMP35979 chydropathy plot

Comments Information

    • Not available

Literature Information

  • ·Literature 1

    • Title

    • Synthetic lipo-polylysine with anti-cancer activity

    • Reference

    • 2023 Sep 26;11(19):6611-6622

    • Author

    • Yi X, Wan P, Shen W, Zhang X, Zhang P, Xiao C.