General Information

    • DRAMP ID

    • DRAMP35990

    • Peptide Name

    • GE18

    • Source

    • Virulence factor of aquatic pathogenic fungus Aphanomyces invadans

    • Family

    • Gene

    • Not found

    • Sequence

    • GAGIVVASIDTGVRVSHE

    • Sequence Length

    • 18

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Anticancer

    • Target Organism

      • Tumor cells: MCF-7 (IC50=29.06μM); MCF-7 (IC50=35.34μM)

    • Hemolytic Activity

      • Not available

    • Cytotoxicity

      • Rat skeletal myoblast cell line (L6): 91.73 ± 2% viability = 10 µM; 90.65 ± 2.9% viability = 20 µM; 87.91 ± 3.05% viability = 30 µM; 87.29 ± 1.9% viability = 40 µM; 84.44 ± 3.8% viability = 50 µM

    • Binding Target

    • Not available

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Amidation

    • C-terminal Modification

    • Acetylation

    • Nonterminal Modifications and Unusual Amino Acids

    • None

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP35990 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP35990.

Physicochemical Information

    • Formula

    • C75H127N23O26

    • Absent Amino Acids

    • CFKLMNPQWY

    • Common Amino Acids

    • V

    • Mass

    • 207039

    • PI

    • 5.45

    • Basic Residues

    • 2

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 8

    • Net Charge

    • 0

    • Boman Index

    • -1204

    • Hydrophobicity

    • 0.622

    • Aliphatic Index

    • 118.89

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 6

DRAMP35990

DRAMP35990 chydropathy plot

Comments Information

    • GE18 affects the cellular morphology, which triggers the cells to undergo apoptosis for biological cellular elimination

Literature Information

  • ·Literature 1

    • Title

    • Aquatic Peptide: The Potential Anti-Cancer and Anti-Microbial Activity of GE18 Derived from Pathogenic Fungus Aphanomyces invadans

    • Reference

    • Molecules. 2023 Sep 21;28(18):6746.

    • Author

    • Velayutham M, Priya PS, Sarkar P, Murugan R, Almutairi BO, Arokiyaraj S, Kari ZA, Tellez-Isaias G, Guru A, Arockiaraj J.