General Information

    • DRAMP ID

    • DRAMP29926

    • Peptide Name

    • synPG-1

    • Source

    • Synthetic construct

    • Family

    • Not found

    • Gene

    • Not found

    • Sequence

    • glrrllrkirgrwkGGGRGGRLCYCRRRFCVCVGR

    • Sequence Length

    • 35

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-

    • Target Organism

      • Gram-negative bacterium: Escherichia coli(MBC=2 µM), Salmonella typhimurium(MIBC=4 µM);
      • Gram-positive bacteria: Methicillin-resistant Staphylococcus aureus(MBC=0.5 µM), Methicillin-resistant Staphylococcus pseudointermedius(MBC=0.5 µM).

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Stability Information

    • Serum or Protease Type

    • Porcine serum

    • Stability Data

    • Incubated in 25% porcine serum for up to 7 or 24 h, maintained strong antimicrobial activity even after 24 h of incubation in serum

    • Assay

    • Colony growth

Structure Information

    • Linear/Cyclic

    • Linear

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • D-Gly at 1st, and 11th position, D-Leu at 2nd, 5th,and 6th position, D-Arg at 3rd, 4th, 7th, 10th, and 12th position, D-Lys at 8th, and 14th position, D-Ile at 9th position, D-Trp at 13th position

    • Stereochemistry

    • Mixed

    • Structure

    • Not found

    • Structure Description

    • Not found

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP29926.

Literature Information

  • ·Literature 1

    • Title

    • The Addition of a Synthetic LPS-Targeting Domain Improves Serum Stability While Maintaining Antimicrobial, Antibiofilm, and Cell Stimulating Properties of an Antimicrobial Peptide

    • Reference

    • Biomolecules. 2020 Jul 8;10(7):1014.

    • Author

    • Maystrenko A, Feng Y, Akhtar N, Li J.