• DRAMP ID

    • DRAMP00001
    • Peptide Name

    • Variacin (Bacteriocin)
    • Source

    • Micrococcus varians (Gram-positive bacteria)
    • Family

    • Belongs to the lantibiotic family (Class I bacteriocin)
    • Gene

    • Not found
    • Sequence

    • GSGVIPTISHECHMNSFQFVFTCCS
    • Sequence Length

    • 25
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+
    • Target Organism

      • Gram-positive bacteria: Lactobacillus helveticus (+++), L. bulgaricus (+++), Lactobacillus lactis (++), Lactobacillus delbrueckii (+++), Lactobacillus acidophilus (++), Lactobacillus plantarum (+), Lactobacillus sake (LSK) (++), Lactobacillus curvatus (++), Leuconostoc mesenteroides (+), Streptococcus thermophilus (++), Lactococcus lactis (SL2) (++), Enterococcus faecalis (++), Enterococcus faecium (++), Listeria innocua (++), Listeria monocytogenes (++++), Listeria welhia (++).
      • Note: Inhibitory activity tested with supernatant adjusted to pH 7.
    • Hemolytic Activity

      • Not found
    • Cytotoxicity

      • Not found
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Linear
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • PDB ID

    • None
    • Formula

    • C118H175N31O36S4
    • Absent Amino Acids

    • ADKLRWY
    • Common Amino Acids

    • S
    • Mass

    • 2732.11
    • PI

    • 5.98
    • Basic Residues

    • 2
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 7
    • Net Charge

    • +1
    • Boman Index

    • -12.12
    • Hydrophobicity

    • 0.452
    • Aliphatic Index

    • 54.4
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 5.21
    • Polar Residues

    • 12

DRAMP00001

DRAMP00001 chydropathy plot
    • Function

    • Has a broad host range of inhibition against Gram-positive food spoilage bacteria. Variacin is resistant to heat and pH conditions from 2 to 10.
    • Biophysicochemical properties

    • Variacin is resistant to heat and pH conditions from 2 to 10.
  • ·Literature 1
    • Title

    • Variacin, a new lanthionine-containing bacteriocin produced by Micrococcus varians: comparison to lacticin 481 of Lactococcus lactis.
    • Reference

    • Appl Environ Microbiol. 1996 May;62(5):1799-1802.
    • Author

    • Pridmore D, Rekhif N, Pittet AC, Suri B, Mollet B.