• DRAMP ID

    • DRAMP00006
    • Peptide Name

    • Butyrivibriocin OR79 (Bacteriocin)
    • Source

    • Butyrivibrio fibrisolvens (Gram-positive bacteria)
    • Family

    • Belongs to the lantibiotic family (Class I bacteriocin)
    • Gene

    • bvi79
    • Sequence

    • GNGVIKTISHECHMNTWQFIFTCCS
    • Sequence Length

    • 25
    • Evidence code

    • Predicted
    • Biological Activity

    • Antibacterial
    • Target Organism

      • Gram-positive bacteria: Fibrisolvens, Butyrivibrio crossotus, Clostridium clostridiforme, Lachnospira multiparus, Ruminococcus flavefaciens.
    • Binding Traget

    • Cell membrane
    • Structure

    • Unknow
    • Structure Description

    • Unknow
    • PDB ID

    • Unknow
    • DRAMP00006 helical wheel diagram
    • Formula

    • C124H186N34O36S4
    • Absent Amino Acids

    • ADLPRY
    • Common Amino Acids

    • CIT
    • Mass

    • 3285.56
    • PI

    • 7.35
    • Basic Residues

    • 3
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 7
    • Boman Index

    • -19.85
    • Hydrophobicity

    • 12
    • Aliphatic Index

    • 58.4
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5625
    • Absorbance 280nm

    • 234.38
    • Polar Residues

    • 12
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Amino Acid Distribution

DRAMP00006 chydropathy plot
    • Function

    • Lanthionine-containing peptide antibiotic (lantibiotic). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.
    • PTM

    • Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor.
  • Literature 1
    • Reference

    • Appl Environ Microbiol. 1999 May;65(5):2128-2135.
    • Author

    • Kalmokoff ML, Lu D, Whitford MF, Teather RM.
    • Title

    • Evidence for production of a new lantibiotic (butyrivibriocin OR79A) by the ruminal anaerobe Butyrivibrio fibrisolvens OR79: characterization of the structural gene encoding butyrivibriocin OR79A.