General Information

    • DRAMP ID

    • DRAMP00006

    • Peptide Name

    • Butyrivibriocin OR79 (Bacteriocin)

    • Source

    • Butyrivibrio fibrisolvens (Gram-positive bacteria)

    • Family

    • Belongs to the lantibiotic family (Class I bacteriocin)

    • Gene

    • bvi79

    • Sequence

    • GNGVIKTISHECHMNTWQFIFTCCS

    • Sequence Length

    • 25

    • Protein Existence

    • Predicted

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Fibrisolvens, Butyrivibrio crossotus, Clostridium clostridiforme, Lachnospira multiparus, Ruminococcus flavefaciens.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00006 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00006.

Physicochemical Information

    • Formula

    • C124H186N34O36S4

    • Absent Amino Acids

    • ADLPRY

    • Common Amino Acids

    • CIT

    • Mass

    • 2857.29

    • PI

    • 6.89

    • Basic Residues

    • 3

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +2

    • Boman Index

    • -19.85

    • Hydrophobicity

    • 0.12

    • Aliphatic Index

    • 58.4

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5625

    • Absorbance 280nm

    • 234.38

    • Polar Residues

    • 12

DRAMP00006

DRAMP00006 chydropathy plot

Comments Information

    • Function

    • Lanthionine-containing peptide antibiotic (lantibiotic). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

    • PTM

    • Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor.

Literature Information

  • ·Literature 1

    • Title

    • Evidence for production of a new lantibiotic (butyrivibriocin OR79A) by the ruminal anaerobe Butyrivibrio fibrisolvens OR79: characterization of the structural gene encoding butyrivibriocin OR79A.

    • Reference

    • Appl Environ Microbiol. 1999 May;65(5):2128-2135.

    • Author

    • Kalmokoff ML, Lu D, Whitford MF, Teather RM.