• DRAMP ID

    • DRAMP00010
    • Peptide Name

    • Plantaricin W alpha (Plw-alpha; Bacteriocin)
    • Source

    • Lactobacillus plantarum (Gram-positive bacteria)
    • Family

    • Belongs to the lantibiotic family (Class I bacteriocin)
    • Gene

    • plWalpha
    • Sequence

    • KCKWWNISCDLGNNGHVCTLSHECQVSCN
    • Sequence Length

    • 29
    • Evidence code

    • Predicted
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+
    • Target Organism

      • Gram-positive bacteria: Lactobacillus spp, Lactococcus lactis, Listeria innocua, Listeria monocytogenes, Oenococcus oeni, Leuconostoc mesenteroides, Pediococcus acidilactici, Pediococcus pentosaceus, Enterococcus faecalis, Propionibacterium freudenreichii, Staphylococcus aureus.
    • Hemolytic Activity

      • N/A
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Free
    • Other Modifications and Unusual Amino Acids

    • Disulfide bond between Cys2 and Cys9,two lanthionines (S8-C18,S21-C28),one β-methyllanthionine(T19-C24).
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Formula

    • C136H208N42O43S5
    • Absent Amino Acids

    • AFMPRY
    • Common Amino Acids

    • C
    • Mass

    • 3779.34
    • PI

    • 7.25
    • Basic Residues

    • 4
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 7
    • Boman Index

    • -45.04
    • Hydrophobicity

    • -0.393
    • Aliphatic Index

    • 60.34
    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 11250
    • Absorbance 280nm

    • 401.79
    • Polar Residues

    • 15

DRAMP00010

DRAMP00010 chydropathy plot
    • Function

    • Plantaricin W (Plw) is a new two-peptide bacteriocin, from Lactobacillus plantarum, which inhibits a large number of Gram-positive bacteria. The two individual peptides, Plwalpha (comprising 29 residues) and Plwbeta (comprising 32 residues), had low antimicrobial activity but acted synergistically. The data indicate that the two peptides work in a 1
    • PTM

    • Chemical analyses showed that both peptides are lantibiotics, but two unmodified cysteines and one serine residue were present in Plwa, and Plwb contained one cysteine residue.
  • ·Literature 1
    • Title

    • Plantaricin W from Lactobacillus plantarum belongs to a new family of two-peptide lantibiotics.
    • Reference

    • Microbiology. 2001 Mar;147(Pt 3):643-651.
    • Author

    • Holo H, Jeknic Z, Daeschel M, Stevanovic S, Nes IF.