General Information

    • DRAMP ID

    • DRAMP00010

    • Peptide Name

    • Plantaricin W alpha (Plw-alpha; Bacteriocin)

    • Source

    • Lactobacillus plantarum (Gram-positive bacteria)

    • Family

    • Belongs to the lantibiotic family (Class I bacteriocin)

    • Gene

    • plWalpha

    • Sequence

    • KCKWWNISCDLGNNGHVCTLSHECQVSCN

    • Sequence Length

    • 29

    • Protein Existence

    • Predicted

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Lactobacillus spp, Lactococcus lactis, Listeria innocua, Listeria monocytogenes, Oenococcus oeni, Leuconostoc mesenteroides, Pediococcus acidilactici, Pediococcus pentosaceus, Enterococcus faecalis, Propionibacterium freudenreichii, Staphylococcus aureus.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Cyclic

    • N-terminal Modification

    • Free

    • C-terminal Modification

    • Free

    • Nonterminal Modifications and Unusual Amino Acids

    • Disulfide bond between Cys2 and Cys9,two lanthionines (S8-C18,S21-C28),one β-methyllanthionine(T19-C24).

    • Stereochemistry

    • L

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00010 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C136H208N42O43S5

    • Absent Amino Acids

    • AFMPRY

    • Common Amino Acids

    • C

    • Mass

    • 3279.7

    • PI

    • 6.88

    • Basic Residues

    • 4

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +2

    • Boman Index

    • -45.04

    • Hydrophobicity

    • -0.393

    • Aliphatic Index

    • 60.34

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11250

    • Absorbance 280nm

    • 401.79

    • Polar Residues

    • 15

DRAMP00010

DRAMP00010 chydropathy plot

Comments Information

    • Function

    • Plantaricin W (Plw) is a new two-peptide bacteriocin, from Lactobacillus plantarum, which inhibits a large number of Gram-positive bacteria. The two individual peptides, Plwalpha (comprising 29 residues) and Plwbeta (comprising 32 residues), had low antimicrobial activity but acted synergistically. The data indicate that the two peptides work in a 1

    • PTM

    • Chemical analyses showed that both peptides are lantibiotics, but two unmodified cysteines and one serine residue were present in Plwa, and Plwb contained one cysteine residue.

Literature Information

  • ·Literature 1

    • Title

    • Plantaricin W from Lactobacillus plantarum belongs to a new family of two-peptide lantibiotics.

    • Reference

    • Microbiology. 2001 Mar;147(Pt 3):643-651.

    • Author

    • Holo H, Jeknic Z, Daeschel M, Stevanovic S, Nes IF.