• DRAMP ID

    • DRAMP00016
    • Peptide Name

    • Salivaricin 9 (Sal9; Bacteriocin)
    • Source

    • Streptococcus salivarius (Gram-positive bacteria)
    • Family

    • Belongs to the lantibiotic family (Class I bacteriocin)
    • Gene

    • sivA
    • Sequence

    • GNGVVLTLTHECNLATWTKKLKCC
    • Sequence Length

    • 24
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+
    • Target Organism

      • Gram-positive bacteria: Streptococcus pyogenes and some Enterococci.
    • Hemolytic Activity

      • Not found
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Other Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • PDB ID

    • None
    • DRAMP00016 helical wheel diagram
    • Formula

    • C114H190N32O33S3
    • Absent Amino Acids

    • DFIMPQRSY
    • Common Amino Acids

    • LT
    • Mass

    • 2633.14
    • PI

    • 8.66
    • Basic Residues

    • 4
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 8
    • Net Charge

    • +3
    • Boman Index

    • -14.06
    • Hydrophobicity

    • 0.125
    • Aliphatic Index

    • 93.33
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5625
    • Absorbance 280nm

    • 244.57
    • Polar Residues

    • 11

DRAMP00016

DRAMP00016 chydropathy plot
    • Note

    • The Sal9 genetic determinants appear generally (but not always) to be megaplasmid-associated, and production seems often to occur in strains that also produce SalA. As is the case for SalA, the production of Sal9 appears to be autoinducible.
  • ·Literature 1
    • Title

    • Salivaricin 9, a new lantibiotic produced by Streptococcus salivarius.
    • Reference

    • Microbiology. 2011 May;157(Pt 5):1290-1299.
    • Author

    • Wescombe PA, Upton M, Renault P, Wirawan RE, Power D, Burton JP, Chilcott CN, Tagg JR.