General Information

    • DRAMP ID

    • DRAMP00016

    • Peptide Name

    • Salivaricin 9 (Sal9; Bacteriocin)

    • Source

    • Streptococcus salivarius (Gram-positive bacteria)

    • Family

    • Belongs to the lantibiotic family (Class I bacteriocin)

    • Gene

    • sivA

    • Sequence

    • GNGVVLTLTHECNLATWTKKLKCC

    • Sequence Length

    • 24

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Streptococcus pyogenes and some Enterococci.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00016 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00016.

Physicochemical Information

    • Formula

    • C114H190N32O33S3

    • Absent Amino Acids

    • DFIMPQRSY

    • Common Amino Acids

    • LT

    • Mass

    • 2633.14

    • PI

    • 8.66

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 8

    • Net Charge

    • +3

    • Boman Index

    • -14.06

    • Hydrophobicity

    • 0.125

    • Aliphatic Index

    • 93.33

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5625

    • Absorbance 280nm

    • 244.57

    • Polar Residues

    • 11

DRAMP00016

DRAMP00016 chydropathy plot

Comments Information

    • Note

    • The Sal9 genetic determinants appear generally (but not always) to be megaplasmid-associated, and production seems often to occur in strains that also produce SalA. As is the case for SalA, the production of Sal9 appears to be autoinducible.

Literature Information

  • ·Literature 1

    • Title

    • Salivaricin 9, a new lantibiotic produced by Streptococcus salivarius.

    • Reference

    • Microbiology. 2011 May;157(Pt 5):1290-1299.

    • Author

    • Wescombe PA, Upton M, Renault P, Wirawan RE, Power D, Burton JP, Chilcott CN, Tagg JR.