• DRAMP ID

    • DRAMP00017
    • Peptide Name

    • Microbisporicin A1 (Bacteriocin)
    • Source

    • Microbispora corallina (Gram-positive bacteria)
    • Family

    • Belongs to the lantibiotic family (Class I bacteriocin)
    • Gene

    • Unknow
    • Sequence

    • VTSWSLCTPGCTSPGGGSNCSFCC
    • Sequence Length

    • 24
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial
    • Target Organism

      • Human pathogens: L100 Staphylococcus aureus ATCC6538P (MIC≤0.13 μg/ml), L819 Staphylococcus aureus Smith ATCC19636 (MIC≤0.13 μg/ml), L1400 S. aureus MRSA (MIC≤0.13 μg/ml), L613 S. aureus MRSA (MIC≤0.13 μg/ml), L3798 S. aureus VISA (MIC=2 μg/ml), L3798 Staphylococcus epidermidis ATCC12228 (MIC≤0.13 μg/ml), L1729 Staphylococcus haemolyticus met-r (MIC=8 μg/ml), L49 Streptococcus pyogenes (MIC≤0.13 μg/ml), L44 Streptococcus pneumoniae (MIC≤0.13 μg/ml), L559 Enterococcus faecalis (MIC=1 μg/ml), L560 Enterococcus faecalis Van A (MIC=0.5 μg/ml), LA533 Enterococcus faecalis Van A (MIC=1 μg/ml), L568 Enterococcus faecium (MIC=2 μg/ml), L569 Enterococcus faecium Van A (MIC=1 μg/ml), LB518 E. faecium Van A (MIC=2 μg/ml), L884 Lactobacillus garviae (MIC=1 μg/ml), L148 Lactobacillus delbrueckii ATCC04797 (MIC=4 μg/ml), L3607 Clostridium perfringens ATCC13124 (MIC≤0.125 μg/ml), L4018 Clostridium difficile (MIC≤0.125 μg/ml), L4043 Clostridium butyricum (MIC≤0.125 μg/ml), Propionibacterium granulosum ATCC25564 (MIC=0.03 μg/ml), L1329 Propionibacterium acnes (MIC=0.5 μg/ml), Propionibacterium limphophylum ATCC27250 (MIC=0.015 μg/ml), L970 Haemophilus influenzae ATCC19418 (MIC=32 μg/ml), L76 Moraxella catarrhalis ATCC8176 (MIC=0.25 μg/ml), L1613 Neisseria meningitidis ATCC13090V (MIC=0.5 μg/ml), L997 Neisseria gonorrhoeae (MIC=0.25 μg/ml).
    • Hemolytic activity

    • Unknown
    • Binding Traget

    • Unknow
    • Structure

    • Rich
    • Structure Description

    • Unknow
    • PDB ID

    • Unknow
    • DRAMP00017 helical wheel diagram
    • Formula

    • C95H144N26O34S5
    • Absent Amino Acids

    • ADEHIKMQRY
    • Common Amino Acids

    • CS
    • Mass

    • 2765.06
    • PI

    • 5.66
    • Basic Residues

    • 0
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 4
    • Boman Index

    • -6.92
    • Hydrophobicity

    • 33.33
    • Aliphatic Index

    • 28.33
    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5750
    • Absorbance 280nm

    • 250
    • Polar Residues

    • 18

Amino Acid Distribution

DRAMP00017 chydropathy plot
    • Function

    • Microbisporicins A1 displayed similar antibacterial activity by selectively blocking peptidoglycan biosynthesis, leading to cytoplasmic accumulation of the UDP-linked precursor.
    • PTM

    • Microbisporicin A1 contains five ether rings
  • Literature 1
    • Reference

    • Chem Biol. 2008 Jan;15(1):22-31.
    • Author

    • Castiglione F, Lazzarini A, Carrano L, Corti E, Ciciliato I, Gastaldo L, Candiani P, Losi D, Marinelli F, Selva E, Parenti F.
    • Title

    • Determining the structure and mode of action of microbisporicin, a potent lantibiotic active against multiresistant pathogens.