General Information
-
DRAMP ID
- DRAMP00017
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Peptide Name
- Microbisporicin A1 (Bacteriocin)
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Source
- Microbispora corallina (Gram-positive bacteria)
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Family
- Belongs to the lantibiotic family (Class I bacteriocin)
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Gene
- Not found
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Sequence
- VTSWSLCTPGCTSPGGGSNCSFCC
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Sequence Length
- 24
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Swiss_Prot Entry
- No entry found
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Evidence code
- Protein level
Activity Information
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Biological Activity
- Antibacterial, Antimicrobial
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Target Organism
-
- Human pathogens: L100 Staphylococcus aureus ATCC6538P (MIC≤0.13 μg/ml), L819 Staphylococcus aureus Smith ATCC19636 (MIC≤0.13 μg/ml), L1400 S. aureus MRSA (MIC≤0.13 μg/ml), L613 S. aureus MRSA (MIC≤0.13 μg/ml), L3798 S. aureus VISA (MIC=2 μg/ml), L3798 Staphylococcus epidermidis ATCC12228 (MIC≤0.13 μg/ml), L1729 Staphylococcus haemolyticus met-r (MIC=8 μg/ml), L49 Streptococcus pyogenes (MIC≤0.13 μg/ml), L44 Streptococcus pneumoniae (MIC≤0.13 μg/ml), L559 Enterococcus faecalis (MIC=1 μg/ml), L560 Enterococcus faecalis Van A (MIC=0.5 μg/ml), LA533 Enterococcus faecalis Van A (MIC=1 μg/ml), L568 Enterococcus faecium (MIC=2 μg/ml), L569 Enterococcus faecium Van A (MIC=1 μg/ml), LB518 E. faecium Van A (MIC=2 μg/ml), L884 Lactobacillus garviae (MIC=1 μg/ml), L148 Lactobacillus delbrueckii ATCC04797 (MIC=4 μg/ml), L3607 Clostridium perfringens ATCC13124 (MIC≤0.125 μg/ml), L4018 Clostridium difficile (MIC≤0.125 μg/ml), L4043 Clostridium butyricum (MIC≤0.125 μg/ml), Propionibacterium granulosum ATCC25564 (MIC=0.03 μg/ml), L1329 Propionibacterium acnes (MIC=0.5 μg/ml), Propionibacterium limphophylum ATCC27250 (MIC=0.015 μg/ml), L970 Haemophilus influenzae ATCC19418 (MIC=32 μg/ml), L76 Moraxella catarrhalis ATCC8176 (MIC=0.25 μg/ml), L1613 Neisseria meningitidis ATCC13090V (MIC=0.5 μg/ml), L997 Neisseria gonorrhoeae (MIC=0.25 μg/ml).
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Hemolytic Activity
-
- Not found
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Other Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Rich
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Structure Description
- Not found
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PDB ID
- None
-
-
Physicochemical Information
-
Formula
- C95H144N26O34S5
Absent Amino Acids
- ADEHIKMQRY
Common Amino Acids
- CS
Mass
- 2765.06
PI
- 5.66
Basic Residues
- 0
Acidic Residues
- 0
Hydrophobic Residues
- 4
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Boman Index
- -6.92
Hydrophobicity
- 0.333
Aliphatic Index
- 28.33
Half Life
-
- Mammalian:100 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5750
Absorbance 280nm
- 250
Polar Residues
- 18
DRAMP00017

Comments Information
Function
- Microbisporicins A1 displayed similar antibacterial activity by selectively blocking peptidoglycan biosynthesis, leading to cytoplasmic accumulation of the UDP-linked precursor.
PTM
- Microbisporicin A1 contains five ether rings
Literature Information
- ·Literature 1
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Title
- Determining the structure and mode of action of microbisporicin, a potent lantibiotic active against multiresistant pathogens.
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Pubmed ID
- 18215770
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Reference
- Chem Biol. 2008 Jan;15(1):22-31.
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Author
- Castiglione F, Lazzarini A, Carrano L, Corti E, Ciciliato I, Gastaldo L, Candiani P, Losi D, Marinelli F, Selva E, Parenti F.