General Information

    • DRAMP ID

    • DRAMP00021

    • Peptide Name

    • HalA2 (one chain of haloduracin; Bacteriocin)

    • Source

    • Bacillus halodurans C-125 (Gram-positive bacteria)

    • Family

    • Belongs to the lantibiotic family (Class I bacteriocin)

    • Gene

    • Not found

    • Sequence

    • TTWPCATVGVSVALCPTTKCTSQC

    • Sequence Length

    • 24

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00021 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00021.

Physicochemical Information

    • Formula

    • C103H169N27O34S4

    • Absent Amino Acids

    • DEFHIMNRY

    • Common Amino Acids

    • T

    • Mass

    • 2457.88

    • PI

    • 7.58

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +1

    • Boman Index

    • -4.26

    • Hydrophobicity

    • 0.513

    • Aliphatic Index

    • 60.83

    • Half Life

      • Mammalian:7.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5750

    • Absorbance 280nm

    • 250

    • Polar Residues

    • 13

DRAMP00021

DRAMP00021 chydropathy plot

Comments Information

    • Function

    • Active on certain Gram-positive bacteria. HalA2 causes pore formation and K+ efflux.

Literature Information

  • ·Literature 1

    • Title

    • Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic.

    • Reference

    • Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17243-17248.

    • Author

    • McClerren AL, Cooper LE, Quan C, Thomas PM, Kelleher NL, van der Donk WA.