• DRAMP ID

    • DRAMP00021
    • Peptide Name

    • HalA2 (one chain of haloduracin; Bacteriocin)
    • Source

    • Bacillus halodurans C-125 (Gram-positive bacteria)
    • Family

    • Belongs to the lantibiotic family (Class I bacteriocin)
    • Gene

    • Not found
    • Sequence

    • TTWPCATVGVSVALCPTTKCTSQC
    • Sequence Length

    • 24
    • Swiss_Prot Entry

    • No entry found
    • Evidence code

    • Not found
    • Biological Activity

    • Antibacterial, Antimicrobial
    • Target Organism

    • No MICs found in DRAMP database
    • Hemolytic Activity

      • Not found
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Other Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Not found
    • Structure Description

    • Not found
    • DRAMP00021 helical wheel diagram
    • Formula

    • C103H169N27O34S4
    • Absent Amino Acids

    • DEFHIMNRY
    • Common Amino Acids

    • T
    • Mass

    • 2868.31
    • PI

    • 7.92
    • Basic Residues

    • 1
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 7
    • Boman Index

    • -4.26
    • Hydrophobicity

    • 0.513
    • Aliphatic Index

    • 60.83
    • Half Life

      • Mammalian:7.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5750
    • Absorbance 280nm

    • 250
    • Polar Residues

    • 13

DRAMP00021

DRAMP00021 chydropathy plot
    • Function

    • Active on certain Gram-positive bacteria. HalA2 causes pore formation and K+ efflux.
  • ·Literature 1
    • Title

    • Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic.
    • Reference

    • Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17243-17248.
    • Author

    • McClerren AL, Cooper LE, Quan C, Thomas PM, Kelleher NL, van der Donk WA.