General Information
-
DRAMP ID
- DRAMP00035
-
Peptide Name
- Lantibiotic paenibacillin (Bacteriocin)
-
Source
- Paenibacillus polymyxa (Bacillus polymyxa) (Gram-positive bacteria)
-
Family
- Belongs to the type A lantibiotic family (Class I bacteriocin)
-
Gene
- Not found
-
Sequence
- ASIIKTTIKVSKAVCKTLTCICTGSCSNCK
-
Sequence Length
- 30
-
UniProt Entry
- P86013
-
Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
-
- Gram-positive bacteria: Bacillus spp, Clostridium sporogenes, Lactobacillus spp, Lactococcus lactis, Leuconostoc mesenteroides, Listeria spp, Pediococcus cerevisiae, Staphylococcus aureus, Streptococcus agalactiae
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Rich
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- Please click DRAMP00035_predicted_structure.pdb to download.
Physicochemical Information
-
Formula
- C129H234N36O41S5
Absent Amino Acids
- DEFHMPQRWY
Common Amino Acids
- CKT
Mass
- 3105.79
PI
- 9.27
Basic Residues
- 5
Acidic Residues
- 0
Hydrophobic Residues
- 9
Net Charge
- +5
-
Boman Index
- -17.2
Hydrophobicity
- 0.54
Aliphatic Index
- 91
Half Life
-
- Mammalian:4.4 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 250
Absorbance 280nm
- 8.62
Polar Residues
- 16
DRAMP00035
Comments Information
Function
- Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. Lacks antibacterial activity against Gram-negative bacteria.
Physicochemical properties
- water solubility, thermal resistance, and stability against acid/alkali (pH 2.0 to 9.0) treatment.
Literature Information
- ·Literature 1
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Title
- Isolation and identification of a Paenibacillus polymyxa strain that coproduces a novel lantibiotic and polymyxin.
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Pubmed ID
- 17071789
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Reference
- Appl Environ Microbiol. 2007 Jan;73(1):168-178.
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Author
- He Z, Kisla D, Zhang L, Yuan C, Green-Church KB, Yousef AE.
- ·Literature 2
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Title
- N-terminal acetylation in paenibacillin, a novel lantibiotic.
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Pubmed ID
- 18625234
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Reference
- FEBS Lett. 2008 Aug 6;582(18):2787-2792.
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Author
- He Z, Yuan C, Zhang L, Yousef AE.