General Information

    • DRAMP ID

    • DRAMP00035

    • Peptide Name

    • Lantibiotic paenibacillin (Bacteriocin)

    • Source

    • Paenibacillus polymyxa (Bacillus polymyxa) (Gram-positive bacteria)

    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)

    • Gene

    • Not found

    • Sequence

    • ASIIKTTIKVSKAVCKTLTCICTGSCSNCK

    • Sequence Length

    • 30

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Bacillus spp, Clostridium sporogenes, Lactobacillus spp, Lactococcus lactis, Leuconostoc mesenteroides, Listeria spp, Pediococcus cerevisiae, Staphylococcus aureus, Streptococcus agalactiae

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Rich

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00035 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00035.

Physicochemical Information

    • Formula

    • C129H234N36O41S5

    • Absent Amino Acids

    • DEFHMPQRWY

    • Common Amino Acids

    • CKT

    • Mass

    • 3105.79

    • PI

    • 9.27

    • Basic Residues

    • 5

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 9

    • Net Charge

    • +5

    • Boman Index

    • -17.2

    • Hydrophobicity

    • 0.54

    • Aliphatic Index

    • 91

    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 250

    • Absorbance 280nm

    • 8.62

    • Polar Residues

    • 16

DRAMP00035

DRAMP00035 chydropathy plot

Comments Information

    • Function

    • Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. Lacks antibacterial activity against Gram-negative bacteria.

    • Physicochemical properties

    • water solubility, thermal resistance, and stability against acid/alkali (pH 2.0 to 9.0) treatment.

Literature Information

  • ·Literature 1

    • Title

    • Isolation and identification of a Paenibacillus polymyxa strain that coproduces a novel lantibiotic and polymyxin.

    • Reference

    • Appl Environ Microbiol. 2007 Jan;73(1):168-178.

    • Author

    • He Z, Kisla D, Zhang L, Yuan C, Green-Church KB, Yousef AE.
  • ·Literature 2

    • Title

    • N-terminal acetylation in paenibacillin, a novel lantibiotic.

    • Reference

    • FEBS Lett. 2008 Aug 6;582(18):2787-2792.

    • Author

    • He Z, Yuan C, Zhang L, Yousef AE.