• DRAMP ID

    • DRAMP00035
    • Peptide Name

    • Lantibiotic paenibacillin (Bacteriocin)
    • Source

    • Paenibacillus polymyxa (Bacillus polymyxa) (Gram-positive bacteria)
    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)
    • Gene

    • Not found
    • Sequence

    • ASIIKTTIKVSKAVCKTLTCICTGSCSNCK
    • Sequence Length

    • 30
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Anti-Gram+, Antimicrobial
    • Target Organism

      • Gram-positive bacteria: Bacillus spp, Clostridium sporogenes, Lactobacillus spp, Lactococcus lactis, Leuconostoc mesenteroides, Listeria spp, Pediococcus cerevisiae, Staphylococcus aureus, Streptococcus agalactiae
    • Hemolytic Activity

      • Not found
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Other Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Rich
    • Structure Description

    • Not found
    • Formula

    • C129H234N36O41S5
    • Absent Amino Acids

    • DEFHMPQRWY
    • Common Amino Acids

    • CKT
    • Mass

    • 3623.26
    • PI

    • 9.16
    • Basic Residues

    • 5
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 9
    • Boman Index

    • -17.2
    • Hydrophobicity

    • 0.54
    • Aliphatic Index

    • 91
    • Half Life

      • Mammalian:4.4 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 250
    • Absorbance 280nm

    • 8.62
    • Polar Residues

    • 16

DRAMP00035

DRAMP00035 chydropathy plot
    • Function

    • Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. Lacks antibacterial activity against Gram-negative bacteria.
    • Physicochemical properties

    • water solubility, thermal resistance, and stability against acid/alkali (pH 2.0 to 9.0) treatment.
  • ·Literature 1
    • Title

    • Isolation and identification of a Paenibacillus polymyxa strain that coproduces a novel lantibiotic and polymyxin.
    • Reference

    • Appl Environ Microbiol. 2007 Jan;73(1):168-178.
    • Author

    • He Z, Kisla D, Zhang L, Yuan C, Green-Church KB, Yousef AE.
  • ·Literature 2
    • Title

    • N-terminal acetylation in paenibacillin, a novel lantibiotic.
    • Reference

    • FEBS Lett. 2008 Aug 6;582(18):2787-2792.
    • Author

    • He Z, Yuan C, Zhang L, Yousef AE.