General Information

    • DRAMP ID

    • DRAMP00041

    • Peptide Name

    • Mutacin-1140 (Mutacin III; Bacteriocin)

    • Source

    • Streptococcus mutans (Gram-positive bacteria)

    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)

    • Gene

    • lanA

    • Sequence

    • FKSWSLCTPGCARTGSFNSYCC

    • Sequence Length

    • 22

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Streptococcus cricetus E49, Streptococcus rattus BHT-2, Streptococcus mutans NG8, S. mutans OMZ175, S. mutans V100, Streptococcus sobrinus SL1, S. sobrinus ATCC 27352, Streptococcus downeii ATCC 33748, Streptococcus salivarius ATCC 25975, Streptococcus salivariusATCC 27945, Streptococcus mitis ATCC 19950, Streptococcus sanguinis.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00041 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00041.

Physicochemical Information

    • Formula

    • C104H152N28O31S4

    • Absent Amino Acids

    • DEHIMQV

    • Common Amino Acids

    • CS

    • Mass

    • 2418.76

    • PI

    • 8.53

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +2

    • Boman Index

    • -23.97

    • Hydrophobicity

    • 0.005

    • Aliphatic Index

    • 22.27

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 7240

    • Absorbance 280nm

    • 344.76

    • Polar Residues

    • 14

DRAMP00041

DRAMP00041 chydropathy plot

Comments Information

    • Function

    • Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

    • PTM

    • There are one dihydroalanine (Dha)

Literature Information

  • ·Literature 1

    • Title

    • Covalent structure of mutacin 1140 and a novel method for the rapid identification of lantibiotics.

    • Reference

    • Eur J Biochem. 2000 Dec;267(23):6810-6816.

    • Author

    • Smith L, Nov¡k J, Rocca J, McClung S, Hillman JD, Edison AS.