General Information

    • DRAMP ID

    • DRAMP00041

    • Peptide Name

    • Mutacin-1140 (Mutacin III; Bacteriocin)

    • Source

    • Streptococcus mutans (Gram-positive bacteria)

    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)

    • Gene

    • lanA

    • Sequence

    • FKSWSLCTPGCARTGSFNSYCC

    • Sequence Length

    • 22

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria:
        Target OrganismActivity
        Streptococcus cricetus E49-
        Streptococcus rattus BHT-2-
        Streptococcus mutans NG8-
        S. mutans OMZ175-
        S. mutans V100-
        Streptococcus sobrinus SL1-
        S. sobrinus ATCC 27352-
        Streptococcus downeii ATCC 33748-
        Streptococcus salivarius ATCC 25975-
        Streptococcus salivariusATCC 27945-
        Streptococcus mitis ATCC 19950-
        Streptococcus sanguinis-

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00041 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00041.

Physicochemical Information

    • Formula

    • C104H152N28O31S4

    • Absent Amino Acids

    • DEHIMQV

    • Common Amino Acids

    • CS

    • Mass

    • 2418.76

    • PI

    • 8.53

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +2

    • Boman Index

    • -23.97

    • Hydrophobicity

    • 0.005

    • Aliphatic Index

    • 22.27

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 7240

    • Absorbance 280nm

    • 344.76

    • Polar Residues

    • 14

DRAMP00041

DRAMP00041 chydropathy plot

Comments Information

    • Function

    • Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

    • PTM

    • There are one dihydroalanine (Dha)

Literature Information

  • ·Literature 1

    • Title

    • Covalent structure of mutacin 1140 and a novel method for the rapid identification of lantibiotics.

    • Reference

    • Eur J Biochem. 2000 Dec;267(23):6810-6816.

    • Author

    • Smith L, Nov¡k J, Rocca J, McClung S, Hillman JD, Edison AS.