General Information

    • DRAMP ID

    • DRAMP00042

    • Peptide Name

    • Bacteriocin mutacin B-Ny266 (Preclinical)

    • Source

    • Streptococcus mutans Ny266 (Gram-positive bacteria)

    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)

    • Gene

    • Not found

    • Sequence

    • FKSWSFCTPGCAKTGSFNSYCC

    • Sequence Length

    • 22

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacterium: Micrococcus luteus ATCC 272.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Cell membrane

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Rich

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00042 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00042.

Physicochemical Information

    • Formula

    • C107H150N26O31S4

    • Absent Amino Acids

    • DEHILMQRV

    • Common Amino Acids

    • CS

    • Mass

    • 2424.76

    • PI

    • 8.52

    • Basic Residues

    • 2

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 5

    • Net Charge

    • +2

    • Boman Index

    • -16.54

    • Hydrophobicity

    • -0.014

    • Aliphatic Index

    • 4.55

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 7240

    • Absorbance 280nm

    • 344.76

    • Polar Residues

    • 14

DRAMP00042

DRAMP00042 chydropathy plot

Comments Information

    • Function

    • Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

    • PTM

    • There are one dihydroalanines (Dha)

Literature Information

  • ·Literature 1

    • Title

    • Purification and structure of mutacin B-Ny266: a new lantibiotic produced by Streptococcus mutans.

    • Reference

    • FEBS Lett. 1997 Jun 30;410(2-3):275-279.

    • Author

    • Mota-Meira M, Lacroix C, LaPointe G, Lavoie MC.