• DRAMP ID

    • DRAMP00042
    • Peptide Name

    • Bacteriocin mutacin B-Ny266 (Preclinical)
    • Source

    • Streptococcus mutans Ny266 (Gram-positive bacteria)
    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)
    • Gene

    • Not found
    • Sequence

    • FKSWSFCTPGCAKTGSFNSYCC
    • Sequence Length

    • 22
    • Protein Existence

    • Protein level
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+
    • Target Organism

      • Gram-positive bacterium: Micrococcus luteus ATCC 272.
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Cell membrane
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Rich
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP00042 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP00042.
    • Formula

    • C107H150N26O31S4
    • Absent Amino Acids

    • DEHILMQRV
    • Common Amino Acids

    • CS
    • Mass

    • 2424.76
    • PI

    • 8.52
    • Basic Residues

    • 2
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 5
    • Net Charge

    • +2
    • Boman Index

    • -16.54
    • Hydrophobicity

    • -0.014
    • Aliphatic Index

    • 4.55
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 7240
    • Absorbance 280nm

    • 344.76
    • Polar Residues

    • 14

DRAMP00042

DRAMP00042 chydropathy plot
    • Function

    • Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.
    • PTM

    • There are one dihydroalanines (Dha)
  • ·Literature 1
    • Title

    • Purification and structure of mutacin B-Ny266: a new lantibiotic produced by Streptococcus mutans.
    • Reference

    • FEBS Lett. 1997 Jun 30;410(2-3):275-279.
    • Author

    • Mota-Meira M, Lacroix C, LaPointe G, Lavoie MC.