General Information

    • DRAMP ID

    • DRAMP00047

    • Peptide Name

    • Streptin 1 (Bacteriocin)

    • Source

    • Bacillus subtilis A1/3 (Gram-positive bacteria)

    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)

    • Gene

    • Not found

    • Sequence

    • VGSRYLCTPGSCWKLVCFTTTVK

    • Sequence Length

    • 23

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Rich

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00047 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00047.

Physicochemical Information

    • Formula

    • C114H181N29O31S3

    • Absent Amino Acids

    • ADEHIMNQ

    • Common Amino Acids

    • T

    • Mass

    • 2550.05

    • PI

    • 9.11

    • Basic Residues

    • 3

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 7

    • Net Charge

    • +3

    • Boman Index

    • -10.25

    • Hydrophobicity

    • 0.4

    • Aliphatic Index

    • 71.74

    • Half Life

      • Mammalian:100 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 7115

    • Absorbance 280nm

    • 323.41

    • Polar Residues

    • 12

DRAMP00047

DRAMP00047 chydropathy plot

Comments Information

    • Two possible structures have been proposed for streptin 1 due to insufficient info. The first lanthionine S3-C7 and the second methyllanthionine T8-C12 are identical in the two proposed structures. A third intra-bond is either S11-C17 or C17-T19 (or C17-T20 or C17-T21). Compared to Streptin 1, Streptin 2 contains 3 additional residues TPY at the N-terminus. Small quantities of peptides at various degrees of dehydration were also detected.

Literature Information

  • ·Literature 1

    • Title

    • Purification and characterization of streptin, a type A1 lantibiotic produced by Streptococcus pyogenes.

    • Reference

    • Appl Environ Microbiol. 2003 May;69(5):2737-2747.

    • Author

    • Wescombe PA, Tagg JR.