General Information

    • DRAMP ID

    • DRAMP00051

    • Peptide Name

    • Mutacin I (Bacteriocin)

    • Source

    • Streptococcus mutans CH43); also Streptococcus mutans UA140 (Gram-positive bacteria)

    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)

    • Gene

    • Not found

    • Sequence

    • FSSLSLCSLGCTGVKNPSFNSYCC

    • Sequence Length

    • 24

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus, Staphylococcus epidermidis, enterococci, pneumococci, group A streptococci.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00051 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00051.

Physicochemical Information

    • Formula

    • C107H165N27O35S4

    • Absent Amino Acids

    • ADEHIMQRW

    • Common Amino Acids

    • S

    • Mass

    • 2517.89

    • PI

    • 7.88

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 6

    • Net Charge

    • +1

    • Boman Index

    • -10.18

    • Hydrophobicity

    • 0.463

    • Aliphatic Index

    • 60.83

    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 1740

    • Absorbance 280nm

    • 75.65

    • Polar Residues

    • 16

DRAMP00051

DRAMP00051 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.

    • Reference

    • Appl Environ Microbiol. 2000 Aug;66(8):3221-3229.

    • Author

    • Qi F, Chen P, Caufield PW.
  • ·Literature 2

    • Title

    • The group I strain of Streptococcus mutans, UA140, produces both the lantibiotic mutacin I and a nonlantibiotic bacteriocin, mutacin IV.

    • Reference

    • Appl Environ Microbiol. 2001 Jan;67(1):15-21.

    • Author

    • Qi F, Chen P, Caufield PW.