• DRAMP ID

    • DRAMP00053
    • Peptide Name

    • Nisin F (Bacteriocin; Perclinical)
    • Source

    • Lactococcus lactis F10 (Gram-positive bacteria)
    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)
    • Gene

    • Not found
    • Sequence

    • ITSISLCTPGCKTGALMGCNMKTATCNCSVHVSK
    • Sequence Length

    • 34
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+
    • Target Organism

      • Gram-positive bacteria: Staphylococcus aureus, Staphylococcus carnosus, Lactobacillus curvatus N1902, Lactobacillus plantarum, Lactobacillus reuteri.
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

    • No cytotoxicity information found in the reference(s) presented
    • Binding Target

    • Lipid II
    • Linear/Cyclic

    • Cyclic
    • N-terminal Modification

    • Free
    • C-terminal Modification

    • Free
    • Nonterminal Modifications and Unusual Amino Acids

    • There are two dehydroalanines (S5; S33), one dehydrobutyrine (T2), which form one lanthionine (S3-C7) and four β-methyllanthionines (T8-C11; T13-C19; T23-C26; T25-C28).
    • Stereochemistry

    • L
    • Structure

    • Not found
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP00053 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP00053.
    • Formula

    • C140H243N41O46S7
    • Absent Amino Acids

    • DEFQRWY
    • Common Amino Acids

    • CT
    • Mass

    • 3461.14
    • PI

    • 8.78
    • Basic Residues

    • 4
    • Acidic Residues

    • 0
    • Hydrophobic Residues

    • 8
    • Net Charge

    • +4
    • Boman Index

    • -15.74
    • Hydrophobicity

    • 0.397
    • Aliphatic Index

    • 68.82
    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 250
    • Absorbance 280nm

    • 7.58
    • Polar Residues

    • 19

DRAMP00053

DRAMP00053 chydropathy plot
    • Function

    • defense response to Gram-positive bacteria.
  • ·Literature 1
    • Title

    • Characterization of the structural gene encoding nisin F, a new lantibiotic produced by a Lactococcus lactis subsp. lactis isolate from freshwater catfish (Clarias gariepinus).
    • Reference

    • Appl Environ Microbiol. 2008 Jan;74(2):547-549.
    • Author

    • de Kwaadsteniet M, Ten Doeschate K, Dicks LM.