General Information

    • DRAMP ID

    • DRAMP00055

    • Peptide Name

    • Bacteriocin 97518

    • Source

    • Planomonospora sp. (Gram-positive bacteria)

    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)

    • Gene

    • Not found

    • Sequence

    • ITSVSWCTPGCTSEGGGSGCSHCC

    • Sequence Length

    • 24

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria: Escherichia coli, Moraxella catarrhalis.
      • Yeast: Candida albicans.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Rich

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00055 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00055.

Physicochemical Information

    • Formula

    • C90H139N27O35S5

    • Absent Amino Acids

    • ADFKLMNQRY

    • Common Amino Acids

    • CGS

    • Mass

    • 2319.55

    • PI

    • 5.24

    • Basic Residues

    • 1

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 3

    • Net Charge

    • 0

    • Boman Index

    • -13.79

    • Hydrophobicity

    • 0.163

    • Aliphatic Index

    • 28.33

    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 5750

    • Absorbance 280nm

    • 250

    • Polar Residues

    • 18

DRAMP00055

DRAMP00055 chydropathy plot

Comments Information

    • Function

    • It inhibits cell wall synthesis of Gram-positive bacteria, including Staphylococcus aureus (MRSA).

Literature Information

  • ·Literature 1

    • Title

    • A novel lantibiotic acting on bacterial cell wall synthesis produced by the uncommon actinomycete Planomonospora sp.

    • Reference

    • Biochemistry. 2007 May 22;46(20):5884-5895.

    • Author

    • Castiglione F, Cavaletti L, Losi D, Lazzarini A, Carrano L, Feroggio M, Ciciliato I, Corti E, Candiani G, Marinelli F, Selva E.