• DRAMP ID

    • DRAMP00055
    • Peptide Name

    • Bacteriocin 97518
    • Source

    • Planomonospora sp. (Gram-positive bacteria)
    • Family

    • Belongs to the type A lantibiotic family (Class I bacteriocin)
    • Gene

    • Not found
    • Sequence

    • ITSVSWCTPGCTSEGGGSGCSHCC
    • Sequence Length

    • 24
    • UniProt Entry

    • No entry found
    • Protein Existence

    • Not found
    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-
    • Target Organism

      • Gram-negative bacteria: Escherichia coli, Moraxella catarrhalis.
      • Yeast: Candida albicans.
    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry
    • Cytotoxicity

      • Not included yet
    • Binding Target

    • Not found
    • Linear/Cyclic

    • Not included yet
    • N-terminal Modification

    • Not included yet
    • C-terminal Modification

    • Not included yet
    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet
    • Stereochemistry

    • Not included yet
    • Structure

    • Rich
    • Structure Description

    • Not found
    • Helical Wheel Diagram

    • DRAMP00055 helical wheel diagram
    • PDB ID

    • None
    • Predicted Structure

    • There is no predicted structure for DRAMP00055.
    • Formula

    • C90H139N27O35S5
    • Absent Amino Acids

    • ADFKLMNQRY
    • Common Amino Acids

    • CGS
    • Mass

    • 2319.55
    • PI

    • 5.24
    • Basic Residues

    • 1
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 3
    • Net Charge

    • 0
    • Boman Index

    • -13.79
    • Hydrophobicity

    • 0.163
    • Aliphatic Index

    • 28.33
    • Half Life

      • Mammalian:20 hour
      • Yeast:30 min
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 5750
    • Absorbance 280nm

    • 250
    • Polar Residues

    • 18

DRAMP00055

DRAMP00055 chydropathy plot
    • Function

    • It inhibits cell wall synthesis of Gram-positive bacteria, including Staphylococcus aureus (MRSA).
  • ·Literature 1
    • Title

    • A novel lantibiotic acting on bacterial cell wall synthesis produced by the uncommon actinomycete Planomonospora sp.
    • Reference

    • Biochemistry. 2007 May 22;46(20):5884-5895.
    • Author

    • Castiglione F, Cavaletti L, Losi D, Lazzarini A, Carrano L, Feroggio M, Ciciliato I, Corti E, Candiani G, Marinelli F, Selva E.