• DRAMP ID

    • DRAMP00058
    • Peptide Name

    • Lantibiotic duramycin B (Bacteriocin)
    • Source

    • Streptoverticillium strain R2075 (Gram-positive bacteria)
    • Family

    • Belongs to the type B lantibiotic family (Class I bacteriocin)
    • Gene

    • Unknown
    • Sequence

    • CRQSCSFGPLTFVCDGNTK
    • Sequence Length

    • 19
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial, Antimicrobial
    • Target Organism

      • No MICs found on DRAMP database
    • Hemolytic activity

    • Unknown
    • Binding Target

    • Phosphatidylethanolamine
    • Structure

    • Rich
    • Structure Description

    • Unknown
    • DRAMP00058 helical wheel diagram
    • Formula

    • C86H135N25O28S3
    • Absent Amino Acids

    • AEHIMWY
    • Common Amino Acids

    • C
    • Mass

    • 2384.59
    • PI

    • 8.05
    • Basic Residues

    • 2
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 4
    • Boman Index

    • -32.67
    • Hydrophobicity

    • -16.84
    • Aliphatic Index

    • 35.79
    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 125
    • Absorbance 280nm

    • 6.94
    • Polar Residues

    • 10

DRAMP00058

DRAMP00058 chydropathy plot
    • Methyllanthionine rings between residues 1 and18 as well as between residues 5 and 11; a lanthionine occurs between Cys14 and residue 4. In addition, addition of Lys19 to dehydralanine at position 6 forms a lysinoalanine bridge. The Asp residue at position 15 is hydroxylated. Duramycins and cinnamycin specifically binds to phosphatidylethanolamine, thereby indirectly inhibiting the activity of phospholipase A2.

  • Literature 1
    • Reference

    • J Antibiot (Tokyo). 1990 Nov;43(11):1403-1412.
    • Author

    • Fredenhagen A, Fendrich G, Märki F, Märki W, Gruner J, Raschdorf F, Peter HH.
    • Title

    • Duramycins B and C, two new lanthionine containing antibiotics as inhibitors of phospholipase A2. Structural revision of duramycin and cinnamycin.