General Information

    • DRAMP ID

    • DRAMP00059

    • Peptide Name

    • Lantibiotic duramycin C (Bacteriocin)

    • Source

    • Streptomyces griseoluteus R2107 (Gram-positive bacteria)

    • Family

    • Belongs to the type B lantibiotic family (Class I bacteriocin)

    • Gene

    • Not found

    • Sequence

    • CANSCSYGPLTWSCDGNTK

    • Sequence Length

    • 19

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • Bacillus

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • phosphatidylethanolamine

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Rich

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00059 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00059.

Physicochemical Information

    • Formula

    • C82H123N23O30S3

    • Absent Amino Acids

    • EFHIMQRV

    • Common Amino Acids

    • CS

    • Mass

    • 2007.19

    • PI

    • 5.81

    • Basic Residues

    • 1

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 3

    • Net Charge

    • 0

    • Boman Index

    • -28.25

    • Hydrophobicity

    • -0.511

    • Aliphatic Index

    • 25.79

    • Half Life

      • Mammalian:1.2 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 7115

    • Absorbance 280nm

    • 395.28

    • Polar Residues

    • 13

DRAMP00059

DRAMP00059 chydropathy plot

Comments Information

    • Function

    • Acts as inhibitor of phospholipase A2.

    • PTM

    • Methyllanthionine rings between residues 1 and 18 as well as between residues 5 and 11; a lanthionine occurs between Cys14 and residue 4. In addition, addition of Lys19 to dehydralanine at position 6 forms a lysinoalanine bridge. The Asp residue at position 15 is hydroxylated.

Literature Information

  • ·Literature 1

    • Title

    • Duramycins B and C, two new lanthionine containing antibiotics as inhibitors of phospholipase A3. Structural revision of duramycin and cinnamycin.Solution structures of the lantibiotics duramycin B and C.

    • Reference

    • J Antibiot (Tokyo). 1990 Nov;43(11):1403-1412.

    • Author

    • Fredenhagen A, Fendrich G, Märki F, Märki W, Gruner J, Raschdorf F, Peter HH. Zimmermann N, Freund S, Fredenhagen A, Jung G.
  • ·Literature 2

    • Title

    • Reference

    • Eur J Biochem. 1993 Sep 1;216(2):419-428.

    • Author