General Information
-
DRAMP ID
- DRAMP00068
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Peptide Name
- Aureocin A53 (Bacteriocin)
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Source
- Staphylococcus aureus A53 (Gram-positive bacteria)
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Family
- Belongs to the class II bacteriocin
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Gene
- aucA
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Sequence
- MSWLNFLKYIAKYGKKAVSAAWKYKGKVLEWLNVGPTLEWVWQKLKKIAGL
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Sequence Length
- 51
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Swiss_Prot Entry
- Q8GPI4
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Evidence code
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
-
- Gram-positive bacteria: Listeria monocytogenes, Staphylococcus simulans (MIC=100 nM), Staphylococcus aureus (MRSA), Streptococcus agalactiae, Micrococcus luteus (MIC=0.15 nM).
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Hemolytic Activity
-
- Not found
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Cytotoxicity
-
- Not included yet
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Binding Target
- Cell membrane
Structure Information
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Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Other Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Alpha helix
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Structure Description
- Not found
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PDB ID
- None
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-
-
- Please click DRAMP00068_predicted_structure.pdb to download.
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Physicochemical Information
-
Formula
- C291H447N69O65S
Absent Amino Acids
- CDHR
Common Amino Acids
- K
Mass
- 6876.28
PI
- 10.73
Basic Residues
- 10
Acidic Residues
- 2
Hydrophobic Residues
- 24
-
Boman Index
- -7.5
Hydrophobicity
- -0.084
Aliphatic Index
- 101.37
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 31970
Absorbance 280nm
- 639.4
Polar Residues
- 12
DRAMP00068

Comments Information
Function
- Antibacterial peptide. It causes membrane permeation.
Literature Information
- ·Literature 1
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Title
- Biochemical characterisation and genetic analysis of aureocin A53, a new, atypical bacteriocin from Staphylococcus aureus.
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Pubmed ID
- 12054867
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Reference
- J Mol Biol. 2002 Jun 7;319(3):745-756.
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Author
- Netz DJ, Pohl R, Beck-Sickinger AG, Selmer T, Pierik AJ, Bastos Mdo C, Sahl HG.