General Information
-
DRAMP ID
- DRAMP00068
-
Peptide Name
- Aureocin A53 (Bacteriocin)
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Source
- Staphylococcus aureus A53 (Gram-positive bacteria)
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Family
- Belongs to the class II bacteriocin
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Gene
- aucA
-
Sequence
- MSWLNFLKYIAKYGKKAVSAAWKYKGKVLEWLNVGPTLEWVWQKLKKIAGL
-
Sequence Length
- 51
-
UniProt Entry
- Q8GPI4
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
-
- Gram-positive bacteria: Listeria monocytogenes, Staphylococcus simulans (MIC=100 nM), Staphylococcus aureus (MRSA), Streptococcus agalactiae, Micrococcus luteus (MIC=0.15 nM).
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Hemolytic Activity
-
- [Ref.12054867] No hemolytic activity was detected when purified aureocin A53 was spotted on sheep blood agar plates (data not shown in the reference).
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Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
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Binding Target
- Cell membrane
Structure Information
-
Linear/Cyclic
- Linear
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N-terminal Modification
- Formylation
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C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Alpha helix
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- 2N8O
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Predicted Structure
- There is no predicted structure for DRAMP00068.
Physicochemical Information
-
Formula
- C291H447N69O65S
Absent Amino Acids
- CDHR
Common Amino Acids
- K
Mass
- 5984.23
PI
- 10.07
Basic Residues
- 10
Acidic Residues
- 2
Hydrophobic Residues
- 24
Net Charge
- +8
-
Boman Index
- -7.5
Hydrophobicity
- -0.084
Aliphatic Index
- 101.37
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 31970
Absorbance 280nm
- 639.4
Polar Residues
- 12
DRAMP00068
Comments Information
Function
- Antibacterial peptide. It causes membrane permeation.
Literature Information
- ·Literature 1
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Title
- Biochemical characterisation and genetic analysis of aureocin A53, a new, atypical bacteriocin from Staphylococcus aureus.
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Pubmed ID
- 12054867
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Reference
- J Mol Biol. 2002 Jun 7;319(3):745-756.
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Author
- Netz DJ, Pohl R, Beck-Sickinger AG, Selmer T, Pierik AJ, Bastos Mdo C, Sahl HG.