• DRAMP ID

    • DRAMP00068
    • Peptide Name

    • Aureocin A53 (Bacteriocin)
    • Source

    • Staphylococcus aureus A53 (Gram-positive bacteria)
    • Family

    • Belongs to the class II bacteriocin
    • Gene

    • aucA
    • Sequence

    • MSWLNFLKYIAKYGKKAVSAAWKYKGKVLEWLNVGPTLEWVWQKLKKIAGL
    • Sequence Length

    • 51
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial
    • Target Organism

      • Gram-positive bacteria: Listeria monocytogenes, Staphylococcus simulans (MIC=100 nM), Staphylococcus aureus (MRSA), Streptococcus agalactiae, Micrococcus luteus (MIC=0.15 nM).
    • Binding Traget

    • Cell membrane
    • Structure

    • Alpha helix
    • Structure Description

    • Unknow
    • PDB ID

    • Unknow
    • DRAMP00068 helical wheel diagram
    • Formula

    • C291H447N69O65S
    • Absent Amino Acids

    • CDHR
    • Common Amino Acids

    • K
    • Mass

    • 6876.28
    • PI

    • 10.73
    • Basic Residues

    • 10
    • Acidic Residues

    • 2
    • Hydrophobic Residues

    • 24
    • Boman Index

    • -7.5
    • Hydrophobicity

    • -8.43
    • Aliphatic Index

    • 101.37
    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour
    • Extinction Coefficient Cystines

    • 31970
    • Absorbance 280nm

    • 639.4
    • Polar Residues

    • 12
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Amino Acid Distribution

DRAMP00068 chydropathy plot
    • Function

    • Antibacterial peptide. It causes membrane permeation.
  • Literature 1
    • Reference

    • J Mol Biol. 2002 Jun 7;319(3):745-756.
    • Author

    • Netz DJ, Pohl R, Beck-Sickinger AG, Selmer T, Pierik AJ, Bastos Mdo C, Sahl HG.
    • Title

    • Biochemical characterisation and genetic analysis of aureocin A53, a new, atypical bacteriocin from Staphylococcus aureus.