General Information
-
DRAMP ID
- DRAMP00069
-
Peptide Name
- Garvieacin Q (GarQ; Bacteriocin)
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Source
- Lactococcus garvieae BCC 43578 (Gram-positive bacteria)
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Family
- Belongs to the class II bacteriocin
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Gene
- Not found
-
Sequence
- EYHLMNGANGYLTRVNGKTVYRVTKDPVSAVFGVISNCWGSAGAGFGPQH
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Sequence Length
- 50
-
UniProt Entry
- No entry found
-
Protein Existence
- Not found
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
-
- Gram-positive bacteria: Bacillus coagulans JCM 2257, Listeria monocytogenes ATCC 19115, L. garvieae strains, E. faecium D48S52, Lactobacillus plantarum BCC 9546, Lactobacillus sakeii JCM 1157, L. ivanovii DMST 9012 (MIC=0.1-1.6 uM).
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- [Ref.22210221] Purified GarQ, up to 1 mg/mL, was not cytotoxic to Vero (African green monkey kidney), HepG (human liver hepatocarcinoma) and Caco-2 (human colon adenocarcinoma) cell lines. Vero, HepG2 and Caco-2 have 94 ± 8, 97 ± 4 and 89 ± 7 % survival with indicated concentration (1mg/mL) of purified garvieacin Q compared to that of untreated control using the MTT assay.
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Linear
-
N-terminal Modification
- Free
-
C-terminal Modification
- Free
-
Nonterminal Modifications and Unusual Amino Acids
- None
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP00069.
Physicochemical Information
-
Formula
- C237H358N68O69S2
Absent Amino Acids
- ?
Common Amino Acids
- G
Mass
- 5327.98
PI
- 9.06
Basic Residues
- 6
Acidic Residues
- 2
Hydrophobic Residues
- 16
Net Charge
- +4
-
Boman Index
- -50.54
Hydrophobicity
- -0.178
Aliphatic Index
- 66.2
Half Life
-
- Mammalian:1 hour
- Yeast:30 min
- E.coli:>10 hour
Extinction Coefficient Cystines
- 9970
Absorbance 280nm
- 203.47
Polar Residues
- 22
DRAMP00069
Comments Information
Comment
- No comments found on DRAMP database
Literature Information
- ·Literature 1
-
Title
- Garvieacin Q, a novel class II bacteriocin from Lactococcus garvieae BCC 43578.
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Pubmed ID
- 22210221
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Reference
- Appl Environ Microbiol. 2012 Mar;78(5):1619-1623.
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Author
- Tosukhowong A, Zendo T, Visessanguan W, Roytrakul S, Pumpuang L, Jaresitthikunchai J, Sonomoto K.