General Information

    • DRAMP ID

    • DRAMP00102

    • Peptide Name

    • Piscicolin-126 (Pisc126; Bacteriocin)

    • Source

    • Carnobacterium piscicola JG126 (Gram-positive bacteria)

    • Family

    • Belongs to the class IIa bacteriocin

    • Gene

    • pisA

    • Sequence

    • KYYGNGVSCNKNGCTVDWSKAIGIIGNNAAANLTTGGAAGWNKG

    • Sequence Length

    • 44

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • No MICs found in DRAMP database

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00102 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

Physicochemical Information

    • Formula

    • C190H295N57O61S2

    • Absent Amino Acids

    • EFHMPQR

    • Common Amino Acids

    • G

    • Mass

    • 4417.9

    • PI

    • 9.19

    • Basic Residues

    • 4

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +3

    • Boman Index

    • -37.89

    • Hydrophobicity

    • -0.314

    • Aliphatic Index

    • 62.27

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 14105

    • Absorbance 280nm

    • 328.02

    • Polar Residues

    • 25

DRAMP00102

DRAMP00102 chydropathy plot

Comments Information

    • Function

    • Inhibits the growth of several Gram-positive bacteria, especially the food-borne pathogen Listeria monocytogenes, but has no effect on the growth of a number of yeasts and Gram-negative bacteria.

    • PTM

    • Contains one disulfide bond 9-14 (By similarity).

Literature Information

  • ·Literature 1

    • Title

    • Characterization of the chemical and antimicrobial properties of piscicolin 126, a bacteriocin produced by Carnobacterium piscicola JG126.

    • Reference

    • Appl Environ Microbiol. 1996 Aug;62(8):2897-2903.

    • Author

    • Jack RW, Wan J, Gordon J, Harmark K, Davidson BE, Hillier AJ, Wettenhall RE, Hickey MW, Coventry MJ.