• DRAMP ID

    • DRAMP00126
    • Peptide Name

    • Plantaricin E (PlnE; Bacteriocin)
    • Source

    • Lactobacillus plantarum (Gram-positive bacteria)
    • Family

    • Belongs to the class IIb bacteriocin
    • Gene

    • plnE
    • Sequence

    • FNRGGYNFGKSVRHVVDAIGSVAGIRGILKSIR
    • Sequence Length

    • 33
    • Evidence code

    • Protein level
    • Biological Activity

    • Antibacterial
    • Target Organism

      • Gram-positive bacteria: Pediococcus pentosaceus Pac 1.0 (MIC=5 nM), Lactobacillus plantarum 965 (MIC=7 nM), Lactobacillus casei subsp.casei NCDO 161 (MIC=20 nM), Lactobacillus casei NCDO 2713 (MIC=150 nM), Lactobacillus sakei NCDO 2714 (MIC=4 nM), Lactobacillus viridescens NCDO 1655 (MIC=2 nM), Pediococcus pentosaceus NCDO 990 (MIC=30 nM), Lactobacillus sakei 706 (MIC=100 nM), Pediococcus acidilactici CH (MIC=10 nM), Lactobacillus curvatus 89 (MIC=5 nM). [PlnE:PlnF=1:1]
    • Binding Traget

    • Unknow
    • Structure

    • Alpha helix (3 helices; 19 residues)
    • Structure Description

    • In DPC micelles, PlnE has an N-terminal alpha-helix (residues 10-21), and a C-terminal alpha-helix-like structure (residues 25-31). Both helices in plnE are amphiphilic, while the helix in plnF is polar in its N-terminal half and amphiphilic in its C-terminal half. PlnE has two GxxxG motifs which are putative helix-helix interaction motifs, one at residues 5 to 9 and one at residues 20 to 24.
    • PDB ID

    • 2JUI resolved by NMR.
    • DRAMP00126 helical wheel diagram
    • 2JUI-> 
    • Formula

    • C158H259N51O42
    • Absent Amino Acids

    • CEMPQTW
    • Common Amino Acids

    • G
    • Mass

    • 4116.07
    • PI

    • 12.08
    • Basic Residues

    • 7
    • Acidic Residues

    • 1
    • Hydrophobic Residues

    • 13
    • Boman Index

    • -51.8
    • Hydrophobicity

    • 6.67
    • Aliphatic Index

    • 100.3
    • Half Life

      • Mammalian:1.1 hour
      • Yeast:3 min
      • E.coli:2 min
    • Extinction Coefficient Cystines

    • 1490
    • Absorbance 280nm

    • 46.56
    • Polar Residues

    • 12
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Amino Acid Distribution

DRAMP00126 chydropathy plot
    • No comments found on DRAMP database

  • Literature 1
    • Reference

    • Appl Environ Microbiol. 1994 Jan;60(1):160-166.
    • Author

    • Diep DB, HÂ¥varstein LS, Nissen-Meyer J, Nes IF.
    • Title

    • The gene encoding plantaricin A, a bacteriocin from Lactobacillus plantarum C11, is located on the same transcription unit as an agr-like regulatory system.
  • Literature 2
    • Reference

    • Biochim Biophys Acta. 2008 Nov;1784(11):1711-1719.
    • Author

    • Fimland N, Rogne P, Fimland G, Nissen-Meyer J, Kristiansen P.E.
    • Title

    • Three-dimensional structure of the two peptides that constitute the two-peptide bacteriocin plantaricin EF.