General Information
-
DRAMP ID
- DRAMP00137
-
Peptide Name
- Plantaricin S beta (Bacteriocin)
-
Source
- Lactobacillus plantarum LPCO10 (Gram-positive bacteria)
-
Family
- Belongs to the class IIb bacteriocin
-
Gene
- plsB
-
Sequence
- KKKKQSWYAAAGDAIVSFGEGFLNAW
-
Sequence Length
- 26
-
UniProt Entry
- O32830
-
Protein Existence
- Predicted
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
-
Target Organism
- Enterococcus, Lactobacillus, Lactococcus, Leuconostoc.
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- 6GO0
-
Predicted Structure
- There is no predicted structure for DRAMP00137.
Physicochemical Information
-
Formula
- C135H198N34O36
Absent Amino Acids
- CHMPRT
Common Amino Acids
- A
Mass
- 2873.26
PI
- 9.4
Basic Residues
- 4
Acidic Residues
- 2
Hydrophobic Residues
- 12
Net Charge
- +2
-
Boman Index
- -20.48
Hydrophobicity
- -0.323
Aliphatic Index
- 60.38
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 12490
Absorbance 280nm
- 499.6
Polar Residues
- 7
DRAMP00137
Comments Information
Although beta alone appeared to retain a trace of inhibitory activity, the complementary action of both the alpha and beta peptides was required for full bacteriocin activity.
Literature Information
- ·Literature 1
-
Title
- Purification and partial amino acid sequence of plantaricin S, a bacteriocin produced by Lactobacillus plantarum LPCO10, the activity of which depends on the complementary action of two peptides.
-
Pubmed ID
- 8534111
-
Reference
- Appl Environ Microbiol. 1995 Dec;61(12):4459-4463.
-
Author
- Jim©nez-Daz R, Ruiz-Barba JL, Cathcart DP, Holo H, Nes IF, Sletten KH, Warner PJ.
- ·Literature 2
-
Title
- Molecular analysis of the locus responsible for production of plantaricin S, a two-peptide bacteriocin produced by Lactobacillus plantarum LPCO10.
-
Pubmed ID
- 9572965
-
Reference
- Appl. Environ. Microbiol. 1998;64 (5):1871-1877.
-
Author
- Stephens SK, Floriano B, Cathcart DP, Bayley SA, Witt VF, Jim©nez-Daz R, Warner PJ, Ruiz-Barba JL.