General Information
-
DRAMP ID
- DRAMP00139
-
Peptide Name
- Acidocin J1132 beta peptide (Bacteriocin)
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Source
- Lactobacillus acidophilus JCM 1132 (Gram-positive bacteria)
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Family
- Belongs to the class IIb bacteriocin
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Gene
- Not found
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Sequence
- GNPKVAHCASQIGRSTAWGAVSGA
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Sequence Length
- 24
-
UniProt Entry
- Q9R499
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Protein Existence
- Protein level
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- Lactobacillus.
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
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Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
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N-terminal Modification
- Not included yet
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C-terminal Modification
- Not included yet
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Nonterminal Modifications and Unusual Amino Acids
- Not included yet
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Stereochemistry
- Not included yet
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Structure
- Not found
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Structure Description
- Not found
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Helical Wheel Diagram
-
PDB ID
- None
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Predicted Structure
- There is no predicted structure for DRAMP00139.
Physicochemical Information
-
Formula
- C98H157N33O31S
Absent Amino Acids
- DEFLMY
Common Amino Acids
- A
Mass
- 2325.59
PI
- 9.51
Basic Residues
- 3
Acidic Residues
- 0
Hydrophobic Residues
- 9
Net Charge
- +3
-
Boman Index
- -20.66
Hydrophobicity
- -0.058
Aliphatic Index
- 61.25
Half Life
-
- Mammalian:30 hour
- Yeast:>20 hour
- E.coli:>10 hour
Extinction Coefficient Cystines
- 5500
Absorbance 280nm
- 239.13
Polar Residues
- 10
DRAMP00139
Comments Information
Comment
- Acidocin J1132 is a pore-forming bacteriocin that creates cell membrane channels through the "barrel-stave" mechanism. Both alpha and beta had inhibitory activity, and an increase in activity by the complementary action of the two components was observed.
Literature Information
- ·Literature 1
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Title
- Isolation, partial characterization, and mode of action of Acidocin J1132, a two-component bacteriocin produced by Lactobacillus acidophilus JCM 1132.
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Pubmed ID
- 8975617
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Reference
- Appl Environ Microbiol. 1996 Mar;62(3):892-897.
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Author
- Tahara T, Oshimura M, Umezawa C, Kanatani K.