General Information
-
DRAMP ID
- DRAMP00147
-
Peptide Name
- Abp118 beta (Salivaricin CRL1328 beta peptide)
-
Source
- Lactobacillus salivarius (Gram-positive bacteria)
-
Family
- Belongs to the class IIb bacteriocin
-
Gene
- abp118beta
-
Sequence
- KNGYGGSGNRWVHCGAGIVGGALIGAIGGPWSAVAGGISGGFTSCR
-
Sequence Length
- 46
-
UniProt Entry
- Q8KWH9
-
Protein Existence
- Predicted
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial
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Target Organism
- No MICs found in DRAMP database
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Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
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Cytotoxicity
-
- Not included yet
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Not included yet
-
N-terminal Modification
- Not included yet
-
C-terminal Modification
- Not included yet
-
Nonterminal Modifications and Unusual Amino Acids
- Not included yet
-
Stereochemistry
- Not included yet
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP00147.
Physicochemical Information
-
Formula
- C189H291N59O55S2
Absent Amino Acids
- DEMQ
Common Amino Acids
- G
Mass
- 4333.87
PI
- 9.5
Basic Residues
- 4
Acidic Residues
- 0
Hydrophobic Residues
- 16
Net Charge
- +4
-
Boman Index
- 0.43
Hydrophobicity
- 0.294
Aliphatic Index
- 72.17
Half Life
-
- Mammalian:1.3 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 12615
Absorbance 280nm
- 280.33
Polar Residues
- 25
DRAMP00147
Comments Information
Function
- Abp118beta can enhanced the antimicrobial activity.
Literature Information
- ·Literature 1
-
Title
- Characterization of the genetic locus responsible for the production of ABP-118, a novel bacteriocin produced by the probiotic bacterium Lactobacillus salivarius subsp. salivarius UCC118.
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Pubmed ID
- 11932444
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Reference
- Microbiology. 2002 Apr;148(Pt 4):973-984.
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Author
- Flynn S, van Sinderen D, Thornton GM, Holo H, Nes IF, Collins JK.
- ·Literature 2
-
Title
- Characterization of salivaricin CRL 1328, a two-peptide bacteriocin produced by Lactobacillus salivarius CRL 1328 isolated from the human vagina.
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Pubmed ID
- 19591924
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Reference
- Res Microbiol. 2009 Jul-Aug;160(6):401-408.
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Author
- Vera Pingitore E, Hebert E.M, Nader-Macias M.E, Sesma F.