General Information

    • DRAMP ID

    • DRAMP00157

    • Peptide Name

    • Plantaricin S alpha (Bacteriocin)

    • Source

    • Lactobacillus plantarum LPCO10 (Gram-positive bacteria)

    • Family

    • Belongs to the class IIb bacteriocin

    • Gene

    • Not found

    • Sequence

    • RNKLAYNMGHYAGKATIFGLAAWALLA

    • Sequence Length

    • 27

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Enterococcus, Lactobacillus, Lactococcus, Leuconostoc.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00157 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP00157.

Physicochemical Information

    • Formula

    • C136H209N37O33S

    • Absent Amino Acids

    • CDEPQSV

    • Common Amino Acids

    • A

    • Mass

    • 2922.44

    • PI

    • 10

    • Basic Residues

    • 4

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 14

    • Net Charge

    • +4

    • Boman Index

    • 0.94

    • Hydrophobicity

    • 0.337

    • Aliphatic Index

    • 98.15

    • Half Life

      • Mammalian:1 hour
      • Yeast:2 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 8480

    • Absorbance 280nm

    • 326.15

    • Polar Residues

    • 8

DRAMP00157

DRAMP00157 chydropathy plot

Comments Information

    • Although beta alone appeared to retain a trace of inhibitory activity, the complementary action of both the alpha and beta peptides was required for full bacteriocin activity.

Literature Information

  • ·Literature 1

    • Title

    • Purification and partial amino acid sequence of plantaricin S, a bacteriocin produced by Lactobacillus plantarum LPCO10, the activity of which depends on the complementary action of two peptides.

    • Reference

    • Appl Environ Microbiol. 1995 Dec;61(12):4459-4463.

    • Author

    • Jim©nez-D­az R, Ruiz-Barba JL, Cathcart DP, Holo H, Nes IF, Sletten KH, Warner PJ.
  • ·Literature 2

    • Title

    • Molecular analysis of the locus responsible for production of plantaricin S, a two-peptide bacteriocin produced by Lactobacillus plantarum LPCO10.

    • Reference

    • Appl. Environ. Microbiol. 1998;64 (5):1871-1877.

    • Author

    • Stephens SK, Floriano B, Cathcart DP, Bayley SA, Witt VF, Jim©nez-D­az R, Warner PJ, Ruiz-Barba JL.