General Information

    • DRAMP ID

    • DRAMP00160

    • Peptide Name

    • ThmA (chain a of Thermophilin 13; Bacteriocin)

    • Source

    • Streptococcus thermophilus (Gram-positive bacteria)

    • Family

    • Belongs to the class IIb bacteriocin

    • Gene

    • Not found

    • Sequence

    • YSGKDXLKDMGGYALAGAGSGALXGAPAGXVGALPGAFVGAHVGAIAG

    • Sequence Length

    • 48

    • UniProt Entry

    • No entry found

    • Protein Existence

    • Not found

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram+

    • Target Organism

      • Gram-positive bacteria: Streptococcus thermophilus SFi3, Clostridium botulinum, Listeria monocytogenes, Bacillus cereus.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00160 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00160.

Physicochemical Information

    • Formula

    • C178H273N49O51S

    • Absent Amino Acids

    • CENQRTW

    • Common Amino Acids

    • G

    • Mass

    • 4335.52

    • PI

    • 6.74

    • Basic Residues

    • 3

    • Acidic Residues

    • 2

    • Hydrophobic Residues

    • 20

    • Net Charge

    • +1

    • Boman Index

    • 33.9

    • Hydrophobicity

    • 0.546

    • Aliphatic Index

    • 81.67

    • Half Life

      • Mammalian:2.8 hour
      • Yeast:10 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 2980

    • Absorbance 280nm

    • 63.4

    • Polar Residues

    • 17

DRAMP00160

DRAMP00160 chydropathy plot

Comments Information

    • Comment

    • No comments found on DRAMP database

Literature Information

  • ·Literature 1

    • Title

    • Thermophilin 13, a nontypical antilisterial poration complex bacteriocin, that functions without a receptor.

    • Reference

    • J Biol Chem. 1997 May 30;272(22):14277-14284.

    • Author

    • Marciset O, Jeronimus-Stratingh MC, Mollet B, Poolman B.