General Information
-
DRAMP ID
- DRAMP00173
-
Peptide Name
- Leucocyclicin Q (Bacteriocin)
-
Source
- Leuconostoc mesenteroides TK41401 (Gram-positive bacteria)
-
Family
- Belongs to the class IIc bacteriocin
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Gene
- lcyQ
-
Sequence
- LVNQLGISKSLANTILGAIAVGNLASWVLALVPGPGWATKAALATAETIVKHEGKAAAIAW
-
Sequence Length
- 61
-
UniProt Entry
- G5ELQ0
-
Protein Existence
- Predicted
Activity Information
-
Biological Activity
- Antimicrobial, Antibacterial, Anti-Gram+
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Target Organism
-
- Gram-positive bacteria: Lactococcus lactis ssp. lactis JCM 7638 (MIC=0.038 µM), L. lactis ssp. lactis ATCC 19435 (MIC=0.038 µM), L. sp. QU 12 (MIC=1.203 µM), Lactobacillus sakei ssp. sakei JCM 1157 (MIC=0.038 µM), Weissella cibaria JCM 12495 (MIC=2.405 µM), W. paramesenteroides JCM 9890 (MIC=0.075 µM), Pediococcus pentosaceus JCM 5885 (MIC=2.405 µM), P. dextrinicus JCM 5887 (MIC=0.038 µM), Enterococcus faecium JCM 5804 (MIC=0.038 µM), E. faecalis JCM 5803 (MIC=0.15 µM), Streptococcus salivarius JCM 5707 (MIC=2.405 µM), S. bovis JCM 5802 (MIC=0.601 µM), S. mutans JCM 5705 (MIC=19.25 µM), Bacillus coagulans JCM 2257 (MIC=0.075 µM), B. subtilis ssp. subtilis JCM 1465 (MIC=0.601 µM), B. cereus JCM 2152 (MIC=2.405 µM), Kocuria rhizophila NBRC 12708 (MIC=9.623 µM), Listeria innocua ATCC 33090 (MIC=0.601 µM), Leuconostoc mesenteroides ssp. mes. JCM 6124 (MIC=0.3 µM), Escherichia coli JM109 (MIC=38.49 µM), E. coli NBRC 3301 (MIC=38.49 µM)
-
Hemolytic Activity
-
- No hemolysis information or data found in the reference(s) presented in this entry
-
Cytotoxicity
- No cytotoxicity information found in the reference(s) presented
-
Binding Target
- Not found
Structure Information
-
Linear/Cyclic
- Cyclic
-
N-terminal Modification
- Cyclization (N termini to C termini)
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C-terminal Modification
- Cyclization (C termini to N termini)
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Nonterminal Modifications and Unusual Amino Acids
- The whole peptide has a cyclic structure in which N and C termini are bound to each other.
-
Stereochemistry
- L
-
Structure
- Not found
-
Structure Description
- Not found
-
Helical Wheel Diagram
-
PDB ID
- None
-
Predicted Structure
- There is no predicted structure for DRAMP00173.
Physicochemical Information
-
Formula
- C282H460N74O77
Absent Amino Acids
- CDFMRY
Common Amino Acids
- A
Mass
- 6119.2
PI
- 9.53
Basic Residues
- 5
Acidic Residues
- 2
Hydrophobic Residues
- 35
Net Charge
- +3
-
Boman Index
- 35.71
Hydrophobicity
- 0.751
Aliphatic Index
- 129.84
Half Life
-
- Mammalian:5.5 hour
- Yeast:3 min
- E.coli:2 min
Extinction Coefficient Cystines
- 16500
Absorbance 280nm
- 275
Polar Residues
- 16
DRAMP00173
Comments Information
Function
- This precursor showed high similarity to the precursor of lactocyclicin Q, a cyclic bacteriocin produced by Lactococcus sp. strain QU 12. This is the first report of a cyclic bacteriocin produced by a strain of the genus Leuconostoc.
Literature Information
- ·Literature 1
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Title
- Identification and characterization of leucocyclicin Q, a novel cyclic bacteriocin produced by Leuconostoc mesenteroides TK41401.
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Pubmed ID
- 21948835
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Reference
- Appl Environ Microbiol. 2011 Nov;77(22):8164-8170.
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Author
- Masuda Y, Ono H, Kitagawa H, Ito H, Mu F, Sawa N, Zendo T, Sonomoto K.