General Information

    • DRAMP ID

    • DRAMP00181

    • Peptide Name

    • Lactococcin-A (LCN-A; Bacteriocin)

    • Source

    • Lactococcus lactis subsp (Streptococcus cremoris) (Gram-positive bacteria)

    • Family

    • Belongs to the class IId bacteriocin

    • Gene

    • lcnA

    • Sequence

    • KLTFIQSTAAGDLYYNTNTHKYVYQQTQNAFGAAANTIVNGWMGGAAGGFGLHH

    • Sequence Length

    • 54

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial

    • Target Organism

    • Lactococcus.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • Not found

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Not found

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00181 helical wheel diagram

    • PDB ID

    • None

    • Predicted Structure

    • There is no predicted structure for DRAMP00181.

Physicochemical Information

    • Formula

    • C260H380N72O77S

    • Absent Amino Acids

    • CEPR

    • Common Amino Acids

    • AG

    • Mass

    • 5778.37

    • PI

    • 8.36

    • Basic Residues

    • 5

    • Acidic Residues

    • 1

    • Hydrophobic Residues

    • 19

    • Net Charge

    • +4

    • Boman Index

    • -40.24

    • Hydrophobicity

    • -0.244

    • Aliphatic Index

    • 61.67

    • Half Life

      • Mammalian:1.3 hour
      • Yeast:3 min
      • E.coli:2 min

    • Extinction Coefficient Cystines

    • 11460

    • Absorbance 280nm

    • 216.23

    • Polar Residues

    • 24

DRAMP00181

DRAMP00181 chydropathy plot

Comments Information

    • Domain

    • Contains one Transmembrane helix at position 9-31 (Potential).

Literature Information

  • ·Literature 1

    • Title

    • Organization and nucleotide sequences of two lactococcal bacteriocin operons.

    • Reference

    • Appl Environ Microbiol. 1991 Feb;57(2):492-498.

    • Author

    • van Belkum MJ, Hayema BJ, Jeeninga RE, Kok J, Venema G.
  • ·Literature 2

    • Title

    • Lactococcin A, a new bacteriocin from Lactococcus lactis subsp. cremoris: isolation and characterization of the protein and its gene.

    • Reference

    • J Bacteriol. 1991 Jun;173(12):3879-3887.

    • Author

    • Holo H, Nilssen O, Nes IF.