General Information

    • DRAMP ID

    • DRAMP00192

    • Peptide Name

    • Microcin C7 (MccC7; Microcin C51, MccC51; Bacteriocin)

    • Source

    • Escherichia coli (Gram-negative bacteria)

    • Family

    • Belongs to the class I microcin

    • Gene

    • mccA

    • Sequence

    • MRTGNAN

    • Sequence Length

    • 7

    • Protein Existence

    • Protein level

Activity Information

    • Biological Activity

    • Antimicrobial, Antibacterial, Anti-Gram-

    • Target Organism

      • Gram-negative bacteria: Enterobacteria including species of Klebsiella, Salmonella, Shigella, Yersinia and Proteus, strains of Escherichia coli.

    • Hemolytic Activity

      • No hemolysis information or data found in the reference(s) presented in this entry

    • Cytotoxicity

      • Not included yet

    • Binding Target

    • It targets the aspartyl-tRNA synthetase

Structure Information

    • Linear/Cyclic

    • Not included yet

    • N-terminal Modification

    • Not included yet

    • C-terminal Modification

    • Not included yet

    • Nonterminal Modifications and Unusual Amino Acids

    • Not included yet

    • Stereochemistry

    • Not included yet

    • Structure

    • Beta strand

    • Structure Description

    • Not found

    • Helical Wheel Diagram

    • DRAMP00192 helical wheel diagram

    • Predicted Structure

    • There is no predicted structure for DRAMP00192.

Physicochemical Information

    • Formula

    • C28H50N12O11S

    • Absent Amino Acids

    • CDEFHIKLPQSVWY

    • Common Amino Acids

    • N

    • Mass

    • 762.84

    • PI

    • 9.5

    • Basic Residues

    • 1

    • Acidic Residues

    • 0

    • Hydrophobic Residues

    • 1

    • Net Charge

    • +1

    • Boman Index

    • -25.67

    • Hydrophobicity

    • -1.271

    • Aliphatic Index

    • 14.29

    • Half Life

      • Mammalian:30 hour
      • Yeast:>20 hour
      • E.coli:>10 hour

    • Extinction Coefficient Cystines

    • 0

    • Absorbance 280nm

    • 0

    • Polar Residues

    • 4

DRAMP00192

Comments Information

    • Function

    • Inhibits protein translation by blocking aspartyl-tRNA synthetase Function

Literature Information

  • ·Literature 1

    • Title

    • Structural and functional diversity of microcins, gene-encoded antibacterial peptides from enterobacteria.

    • Reference

    • J Mol Microbiol Biotechnol. 2007;13(4):200-209.

    • Author

    • Duquesne S, Petit V, Peduzzi J, Rebuffat S.
  • ·Literature 2

    • Title

    • Low-molecular-weight post-translationally modified microcins.

    • Reference

    • Mol Microbiol. 2007 Sep;65(6):1380-1394.

    • Author

    • Severinov K, Semenova E, Kazakov A, Kazakov T, Gelfand MS.
  • ·Literature 3

    • Title

    • How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic.

    • Reference

    • EMBO J. 2009 Jul 8;28(13):1953-1964.

    • Author

    • Regni CA, Roush RF, Miller DJ, Nourse A, Walsh CT, Schulman BA.